Bell Paralizisi Olan Hastalarda Hematolojik Parametrelerin Prognostik Değeri Var Mıdır?

Muhammed Gazi Yıldız; İsrafil Orhan; İrfan Kara; Saime Sağıroğlu; Nagihan Bilal; Adem Doğaner; Muhammed Seyithanoğlu

doi:10.46332/aemj.1008500

Research Article

Bell Paralizisi Olan Hastalarda Hematolojik Parametrelerin Prognostik Değeri Var Mıdır?

Year 2022, Volume: 6 Issue: 3, 304 - 309, 25.12.2022

Muhammed Gazi Yıldız İsrafil Orhan İrfan Kara Saime Sağıroğlu Nagihan Bilal Adem Doğaner Muhammed Seyithanoğlu

https://doi.org/10.46332/aemj.1008500

Abstract

Amaç: Bu çalışmanın amacı, Bell Paralizisi (BP) olan hastalarda Sistemik İmmun İnflamasyon İndeksi (SII), Nötrofil/Lenfosit Oranı (NLO), Platelet/Lenfosit Oranının (PLO) prognoza katkısını araştırmaktı.

Araçlar ve Yöntem: BP tanısı olan 71 hasta ve kontrol grubu 40 kişi olan katılımcıların verileri retrospektif olarak değerlendirildi. Çalışma kapsamında hastaların yaşları, cinsiyetleri, BP tarafı, House-Brackmann Skorlama (HBS) sistemine göre evreleri, NLO, PLO ve SII oranları ayrıntılı olarak değerlendirildi. BP grubu, Ayrıca BP hastalarda ROC analizi yapılmış, prognostik önemi olabilecek parametreler değerlendirildi.

Bulgular: Yaş ve cinsiyet dağılımı açısından gruplar uyumlu idi. BP hastalarında NLO, PLO, SII değerlerindeki yükseklik istatistiksel açıdan anlamlı idi. ROC analizinde özellikle SII parametresi prognoz açısından daha değerli bulundu.

Sonuç: BP inflamatuar bir bileşeni mevcuttur. SII, NLO, PLO inflamatuar durumu gösterir ve prognostik belirteç olarak kullanılabilir.

Keywords

fasiyal paralizi, inflamasyon, sistemik immun inflamasyon indeksi

References

1. Kefalidis G, Riga M, Argyropoulou P et al. Is the width of the labyrinthine portion of the fallopian tube implicated in the pathophysiology of Bell's palsy?: a prospective clinical study using computed tomography. Laryngoscope. 2010;120(6):1203-1207.
2. Mavrikakis I. Facial nerve palsy: anatomy, etiology, evaluation, and management. Orbit. 2008;27(6):466-474.
3. Murakami S, Mizobuchi M, Nakashiro Y, Doi T, Hato N, Yanagihara N. Bell palsy and herpes simplex virus: identifi-cation of viral DNA in endoneurial fluid and muscle. Ann Intern Med. 1996;124(1):27-30.
4. Kang TS, Vrabec JT, Giddings N, Terris DJ. Facial nerve grading systems (1985-2002): beyond the House-Brackmann scale. Otol Neurotol. 2002;23(5):767-771.
5. Takemoto N, Horii A, Sakata Y, Inohara H. Prognostic factors of peripheral facial palsy: Multivariate analysis followed by receiver operating characteristic and Kaplan-Meier analyses. Otol Neurotol. 2011;32(6):1031-1036.
6. Takenaka Y, Oya R, Kitamiura T et al. Prognostic role of neutrophil-to-lymphocyte ratio in head and neck cancer: A meta-analysis. Head Neck. 2018;40(3):647-655.
7. Zhou X, Du Y, Huang Z, et al. Prognostic value of PLR in various cancers: A meta-analysis. PLoS One. 2014;26(6):e101119.
8. Yang R, Chang Q, Meng X, Gao N, Wang W. Prognostic value of systemic immune-inflammation index in cancer: a meta-analysis. J Cancer. 2018;9(18): 3295-3302.
9. Özler GS, Günak G. Neutrophil-lymphocyte ratio: A new predictive and prognostic factor in patients with Bell palsy. J Craniofac Surg. 2014;25(3):944-945.
10. Sahin C, Varim C. Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume and red cell distribution width measures in Bells Palsy. Open Access Maced J Med Sci. 2017;5(1):14-18.
11. Kiliçkaya MM, Tuz M, Yarikta M, Yasan H, Aynali G, Bagci Ö. The importance of the neutrophil-lymphocyte ratio in patients with idiopathic peripheral facial palsy. Int J Otolaryngol. 2015;215:981950.
12. Greco A, Gallo A, Fusconi M, Marinelli C, Macri GF, De Vincentiis M. Bell's palsy and autoimmunity. Autoimmun Rev. 2012;12(2):323-328.
13. Yilmaz M, Tarakcioglu M, Bayazit N, Bayazit YA, Namiduru M, Kanlikama M. Serum cytokine levels in Bell's palsy. J Neurol Sci. 2002;197(1-2):69-72.
14. Looker KJ, Magaret AS, May MT, et al. Global and regional estimates of prevalence and incident herpes simplex virus type 1 infections in 2012. PLoS One. 2015;28(10):e0140765.
15. Zhang W, Xu L, Luo T, Wu F, Zhao B, Li X. The etiology of Bell’s palsy: a review. J. Neurol. 2020;267(7):1896-1905.
16. Büyükkoyuncu Pekel, N., Yildiz, D., Sığırlı D., Yabaci, A, Seferoğlu, M., & Güneş, A. (2018). Parkinson’s Disease: Is It Actually An Inflammatory Disorder? Turk Geriatri Derg. 2018;21(4):483-489.
17. Bucak, A. Ulu, S. Oruc, S et al. Neutrophil-to-lymphocyte ratio as a novel-potential marker for predicting prognosis of Bell palsy. The Laryngoscope. 2014;124(7):1678-1681.
18. Ozler GS, Gunak G. Neutrophil-Lymphocyte Ratio: A New Predictive and Prognostic Factor in Patients With Bell Palsy. J. Craniofac. Surg. 2014;25(3):944-945.
19. Deveci İ, Sürmeli M. Correlation of Systemic ImmuneInflammation Index and Neutrophil-to-Lymphocyte Ratio with Histopathological Findings in Patients with Tongue Cancer. Haydarpasa Numune Med J. 2018;58(3):122-127.
20. Saçmacı, H., Aktürk, T., & Tanık, N. The Predictive Value of the Systemic Immune-inflammation Index as a New Prognostic Marker for Disability in Patients with Multiple Sclerosis. Turk Noroloji Derg. 2021; 27(2):133-139.
21. Heneka MT, Carson MJ, El Khoury J, et al. Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015;14(4):388-405.
22. Kinar A, Ulu S, Bucak A, Kazan E. Can Systemic Immune-Inflammation Index (SII) be a prognostic factor of Bell’s palsy patients? Neurol Sci. 2021;42(8):3197-3201.
23. Ghoshal K, Bhattacharyya M. Overview of platelet physiology: its hemostatic and nonhemostatic role in disease pathogenesis. Sci. World J. 2014;2014:1-16.
24. Ozturk K, Akyildiz NS, Uslu M, Gode S, Uluoz U. The effect of preoperative neutrophil, platelet and lymphocyte counts on local recurrence and survival in early-stage tongue cancer. Eur Arch Otorhinolaryngol. 2016;273(12):4425-4429.
25. Güneş A, Karalı E. Bell's Paralizisi Geçiren Hastalarda Hematolojik Parametrelerin Hastalık Evresi İle İlişkisinin Değerlendirilmesi. KBB-Forum. 2019;18(4): 334-336.
26. Atan D, İkincioğullari A, Köseoğlu S, et al. New predictive parameters of Bell's Palsy: Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. Balkan Med J. 2015;32(2):167-170.
27. Wasano K, Kawasaki T, Yamamoto S, et al. Pretreatment hematologic findings as novel predictive markers for facial palsy prognosis. Otolaryngol Head Neck Surg. 2016;155(4):581-587.
28. Sahin C, Varim C. Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume and red cell distribution width measures in Bells Palsy. Open Access Maced J Med Sci. 2017;5(1):14-18.
29. Ushio M, Kondo K, Takeuchi N, Tojima H, Yamaguchi T, Kaga K. Prediction of the prognosis of Bell's palsy using multivariate analyses. Otol Neurotol. 2008;29(1):69-72.
30. Grosheva M, Wittekindt C, Guntinas-Lichius O. Prognostic value of electroneurography and electromyography in facial palsy. Laryngoscope. 2008;118(3): 394-397.
31. Oya R, Takenaka Y, Imai T et al. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Prognostic Hematologic Markers of Bell's Palsy: A Meta-analysis. Otol Neurotol. 2019;40(5):681-687.
32. Goodman & Gilman's Adrenocortical steroids. The Pharmacological Basis of Therapeutics 9th ed. 1998;59:1465-1485.
33. Wang D, Bai N, Hu X, OuYang XW, Yao L, Tao Y, Wang Z. Preoperative inflammatory markers of NLR and PLR as indicators of poor prognosis in resectable HCC. PeerJ. 2019;7:e7132.
34. Chen C, Yang H, Cai D, Xiang L, Fang W, Wang R. Preoperative peripheral blood neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratio (PLR) related nomograms predict the survival of patients with limited-stage small-cell lung cancer. Transl Lung Cancer Res. 2021;10(2):866-877.
35. Küçük, A., Öztep, Ş. E., YILMAZ, E. B., Topkan, E. Sınırlı evre küçük hücreli akciğer kanseri tanılı hastalarda eşzamanlı kemoradyoterapi öncesi sistemik immün inflamasyon indeksi’nin sağ kalıma etkisi. Mersin Univ Saglık Bilim Derg. 2021;14(2): 186-198.

Can Hematological Parameters Have a Prognostic Value in Bell’s Palsy Patients?

Year 2022, Volume: 6 Issue: 3, 304 - 309, 25.12.2022

Muhammed Gazi Yıldız İsrafil Orhan İrfan Kara Saime Sağıroğlu Nagihan Bilal Adem Doğaner Muhammed Seyithanoğlu

https://doi.org/10.46332/aemj.1008500

Abstract

Purpose: The study aim was to investigate the contribution of the Systemic Immune-Inflammation Index (SII), neutrophil-to-lymphocyte ratio (NLR) and that platelet-to-lymphocyte ratio (PLR) to the prognosis of Bell’s palsy patients.

Materials and Methods: Data of 71 patients with Bell’s palsy and 40 participants in control group were retrospectively evaluated. Within the study scope, patients were assessed in detail according to patient age, gender, BP side, House-Brackmann score (HBS) system grading, NLR, PLR, and SII ratios. In addition, ROC analysis was performed in BP patients, and parameters that may have prognostic significance were evaluated.

Results: The groups were matched in terms of age and gender distribution. NLR, PLR, and SII values were statistically significant in BP patients. Especially SII parameter was found to be more valuable for prognosis in the ROC analysis.

Conclusion: Bell’s palsy has an inflammatory component. SII, NLR, LR values can indicate an inflammatory condition in these patients. They may be used as markers and prognostic indicators in Bell’s palsy.

Keywords

facial paralysis, inflammation, systemic immune inflammation index

References

1. Kefalidis G, Riga M, Argyropoulou P et al. Is the width of the labyrinthine portion of the fallopian tube implicated in the pathophysiology of Bell's palsy?: a prospective clinical study using computed tomography. Laryngoscope. 2010;120(6):1203-1207.
2. Mavrikakis I. Facial nerve palsy: anatomy, etiology, evaluation, and management. Orbit. 2008;27(6):466-474.
3. Murakami S, Mizobuchi M, Nakashiro Y, Doi T, Hato N, Yanagihara N. Bell palsy and herpes simplex virus: identifi-cation of viral DNA in endoneurial fluid and muscle. Ann Intern Med. 1996;124(1):27-30.
4. Kang TS, Vrabec JT, Giddings N, Terris DJ. Facial nerve grading systems (1985-2002): beyond the House-Brackmann scale. Otol Neurotol. 2002;23(5):767-771.
5. Takemoto N, Horii A, Sakata Y, Inohara H. Prognostic factors of peripheral facial palsy: Multivariate analysis followed by receiver operating characteristic and Kaplan-Meier analyses. Otol Neurotol. 2011;32(6):1031-1036.
6. Takenaka Y, Oya R, Kitamiura T et al. Prognostic role of neutrophil-to-lymphocyte ratio in head and neck cancer: A meta-analysis. Head Neck. 2018;40(3):647-655.
7. Zhou X, Du Y, Huang Z, et al. Prognostic value of PLR in various cancers: A meta-analysis. PLoS One. 2014;26(6):e101119.
8. Yang R, Chang Q, Meng X, Gao N, Wang W. Prognostic value of systemic immune-inflammation index in cancer: a meta-analysis. J Cancer. 2018;9(18): 3295-3302.
9. Özler GS, Günak G. Neutrophil-lymphocyte ratio: A new predictive and prognostic factor in patients with Bell palsy. J Craniofac Surg. 2014;25(3):944-945.
10. Sahin C, Varim C. Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume and red cell distribution width measures in Bells Palsy. Open Access Maced J Med Sci. 2017;5(1):14-18.
11. Kiliçkaya MM, Tuz M, Yarikta M, Yasan H, Aynali G, Bagci Ö. The importance of the neutrophil-lymphocyte ratio in patients with idiopathic peripheral facial palsy. Int J Otolaryngol. 2015;215:981950.
12. Greco A, Gallo A, Fusconi M, Marinelli C, Macri GF, De Vincentiis M. Bell's palsy and autoimmunity. Autoimmun Rev. 2012;12(2):323-328.
13. Yilmaz M, Tarakcioglu M, Bayazit N, Bayazit YA, Namiduru M, Kanlikama M. Serum cytokine levels in Bell's palsy. J Neurol Sci. 2002;197(1-2):69-72.
14. Looker KJ, Magaret AS, May MT, et al. Global and regional estimates of prevalence and incident herpes simplex virus type 1 infections in 2012. PLoS One. 2015;28(10):e0140765.
15. Zhang W, Xu L, Luo T, Wu F, Zhao B, Li X. The etiology of Bell’s palsy: a review. J. Neurol. 2020;267(7):1896-1905.
16. Büyükkoyuncu Pekel, N., Yildiz, D., Sığırlı D., Yabaci, A, Seferoğlu, M., & Güneş, A. (2018). Parkinson’s Disease: Is It Actually An Inflammatory Disorder? Turk Geriatri Derg. 2018;21(4):483-489.
17. Bucak, A. Ulu, S. Oruc, S et al. Neutrophil-to-lymphocyte ratio as a novel-potential marker for predicting prognosis of Bell palsy. The Laryngoscope. 2014;124(7):1678-1681.
18. Ozler GS, Gunak G. Neutrophil-Lymphocyte Ratio: A New Predictive and Prognostic Factor in Patients With Bell Palsy. J. Craniofac. Surg. 2014;25(3):944-945.
19. Deveci İ, Sürmeli M. Correlation of Systemic ImmuneInflammation Index and Neutrophil-to-Lymphocyte Ratio with Histopathological Findings in Patients with Tongue Cancer. Haydarpasa Numune Med J. 2018;58(3):122-127.
20. Saçmacı, H., Aktürk, T., & Tanık, N. The Predictive Value of the Systemic Immune-inflammation Index as a New Prognostic Marker for Disability in Patients with Multiple Sclerosis. Turk Noroloji Derg. 2021; 27(2):133-139.
21. Heneka MT, Carson MJ, El Khoury J, et al. Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015;14(4):388-405.
22. Kinar A, Ulu S, Bucak A, Kazan E. Can Systemic Immune-Inflammation Index (SII) be a prognostic factor of Bell’s palsy patients? Neurol Sci. 2021;42(8):3197-3201.
23. Ghoshal K, Bhattacharyya M. Overview of platelet physiology: its hemostatic and nonhemostatic role in disease pathogenesis. Sci. World J. 2014;2014:1-16.
24. Ozturk K, Akyildiz NS, Uslu M, Gode S, Uluoz U. The effect of preoperative neutrophil, platelet and lymphocyte counts on local recurrence and survival in early-stage tongue cancer. Eur Arch Otorhinolaryngol. 2016;273(12):4425-4429.
25. Güneş A, Karalı E. Bell's Paralizisi Geçiren Hastalarda Hematolojik Parametrelerin Hastalık Evresi İle İlişkisinin Değerlendirilmesi. KBB-Forum. 2019;18(4): 334-336.
26. Atan D, İkincioğullari A, Köseoğlu S, et al. New predictive parameters of Bell's Palsy: Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. Balkan Med J. 2015;32(2):167-170.
27. Wasano K, Kawasaki T, Yamamoto S, et al. Pretreatment hematologic findings as novel predictive markers for facial palsy prognosis. Otolaryngol Head Neck Surg. 2016;155(4):581-587.
28. Sahin C, Varim C. Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume and red cell distribution width measures in Bells Palsy. Open Access Maced J Med Sci. 2017;5(1):14-18.
29. Ushio M, Kondo K, Takeuchi N, Tojima H, Yamaguchi T, Kaga K. Prediction of the prognosis of Bell's palsy using multivariate analyses. Otol Neurotol. 2008;29(1):69-72.
30. Grosheva M, Wittekindt C, Guntinas-Lichius O. Prognostic value of electroneurography and electromyography in facial palsy. Laryngoscope. 2008;118(3): 394-397.
31. Oya R, Takenaka Y, Imai T et al. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Prognostic Hematologic Markers of Bell's Palsy: A Meta-analysis. Otol Neurotol. 2019;40(5):681-687.
32. Goodman & Gilman's Adrenocortical steroids. The Pharmacological Basis of Therapeutics 9th ed. 1998;59:1465-1485.
33. Wang D, Bai N, Hu X, OuYang XW, Yao L, Tao Y, Wang Z. Preoperative inflammatory markers of NLR and PLR as indicators of poor prognosis in resectable HCC. PeerJ. 2019;7:e7132.
34. Chen C, Yang H, Cai D, Xiang L, Fang W, Wang R. Preoperative peripheral blood neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratio (PLR) related nomograms predict the survival of patients with limited-stage small-cell lung cancer. Transl Lung Cancer Res. 2021;10(2):866-877.
35. Küçük, A., Öztep, Ş. E., YILMAZ, E. B., Topkan, E. Sınırlı evre küçük hücreli akciğer kanseri tanılı hastalarda eşzamanlı kemoradyoterapi öncesi sistemik immün inflamasyon indeksi’nin sağ kalıma etkisi. Mersin Univ Saglık Bilim Derg. 2021;14(2): 186-198.

There are 35 citations in total.

Details

Primary Language	Turkish
Subjects	Clinical Sciences
Journal Section	Original Articles
Authors	Muhammed Gazi Yıldız 0000-0002-1880-0685 İsrafil Orhan 0000-0002-9557-7050 İrfan Kara 0000-0003-3884-3014 Saime Sağıroğlu 0000-0003-2608-7274 Nagihan Bilal 0000-0002-2850-3481 Adem Doğaner 0000-0002-0270-9350 Muhammed Seyithanoğlu 0000-0002-8027-7549
Early Pub Date	December 13, 2022
Publication Date	December 25, 2022
Published in Issue	Year 2022 Volume: 6 Issue: 3

Cite

APA	Yıldız, M. G., Orhan, İ., Kara, İ., Sağıroğlu, S., et al. (2022). Bell Paralizisi Olan Hastalarda Hematolojik Parametrelerin Prognostik Değeri Var Mıdır?. Ahi Evran Medical Journal, 6(3), 304-309. https://doi.org/10.46332/aemj.1008500
AMA	Yıldız MG, Orhan İ, Kara İ, Sağıroğlu S, Bilal N, Doğaner A, Seyithanoğlu M. Bell Paralizisi Olan Hastalarda Hematolojik Parametrelerin Prognostik Değeri Var Mıdır?. Ahi Evran Med J. December 2022;6(3):304-309. doi:10.46332/aemj.1008500
Chicago	Yıldız, Muhammed Gazi, İsrafil Orhan, İrfan Kara, Saime Sağıroğlu, Nagihan Bilal, Adem Doğaner, and Muhammed Seyithanoğlu. “Bell Paralizisi Olan Hastalarda Hematolojik Parametrelerin Prognostik Değeri Var Mıdır?”. Ahi Evran Medical Journal 6, no. 3 (December 2022): 304-9. https://doi.org/10.46332/aemj.1008500.
EndNote	Yıldız MG, Orhan İ, Kara İ, Sağıroğlu S, Bilal N, Doğaner A, Seyithanoğlu M (December 1, 2022) Bell Paralizisi Olan Hastalarda Hematolojik Parametrelerin Prognostik Değeri Var Mıdır?. Ahi Evran Medical Journal 6 3 304–309.
IEEE	M. G. Yıldız, “Bell Paralizisi Olan Hastalarda Hematolojik Parametrelerin Prognostik Değeri Var Mıdır?”, Ahi Evran Med J, vol. 6, no. 3, pp. 304–309, 2022, doi: 10.46332/aemj.1008500.
ISNAD	Yıldız, Muhammed Gazi et al. “Bell Paralizisi Olan Hastalarda Hematolojik Parametrelerin Prognostik Değeri Var Mıdır?”. Ahi Evran Medical Journal 6/3 (December 2022), 304-309. https://doi.org/10.46332/aemj.1008500.
JAMA	Yıldız MG, Orhan İ, Kara İ, Sağıroğlu S, Bilal N, Doğaner A, Seyithanoğlu M. Bell Paralizisi Olan Hastalarda Hematolojik Parametrelerin Prognostik Değeri Var Mıdır?. Ahi Evran Med J. 2022;6:304–309.
MLA	Yıldız, Muhammed Gazi et al. “Bell Paralizisi Olan Hastalarda Hematolojik Parametrelerin Prognostik Değeri Var Mıdır?”. Ahi Evran Medical Journal, vol. 6, no. 3, 2022, pp. 304-9, doi:10.46332/aemj.1008500.
Vancouver	Yıldız MG, Orhan İ, Kara İ, Sağıroğlu S, Bilal N, Doğaner A, Seyithanoğlu M. Bell Paralizisi Olan Hastalarda Hematolojik Parametrelerin Prognostik Değeri Var Mıdır?. Ahi Evran Med J. 2022;6(3):304-9.

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