ABSTRACT
Objectives: The goal of this study was to observe the regenerative potential of Tideglusib in combination with autogenous and xenograft mandibular defects in rats.
Material Methods: Our study consists of five groups: one control and four experimental. In 40 Wistar albino rats, 5-mm-diameter critical bone defects were created at the angle of the mandible. In the control group, the defect was not filled. The defects were grafted only Xenograft in Group 1, with Xenograft and tideglusib in Group 2, and with only autogenous bone graft in Group3, and with autogenous bone graft mixed with tideglusib in Group 4.
Results: Sterological analyses revealed that enhanced new bone formation in the Group 4 compare to Control and Group 1. Immunohistochemically marked expressions of BMP-2 and VEGF were observed in Group 4.
Conclusions: Our results demonstrated that Tideglusib, in combination with bone grafting has an adjuvant effect on BMP-2 and VEGF-A expressions that may accelerate bone regeneration.
This study was supported by the Scientific Research Project Fund of Pamukkale University
Project Number: 2018DİŞF011
Project Number: 2018DİŞF011
Primary Language | English |
---|---|
Subjects | Health Care Administration |
Journal Section | Original Research Articles |
Authors | |
Project Number | Project Number: 2018DİŞF011 |
Publication Date | September 15, 2021 |
Submission Date | May 29, 2021 |
Published in Issue | Year 2021Volume: 24 Issue: 3 |
Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.
CDJ accepts articles in English. Submitting a paper to CDJ is free of charges. In addition, CDJ has not have article processing charges.
Frequency: Four times a year (March, June, September, and December)
IMPORTANT NOTICE
All users of Cumhuriyet Dental Journal should visit to their user's home page through the "https://dergipark.org.tr/tr/user" " or "https://dergipark.org.tr/en/user" links to update their incomplete information shown in blue or yellow warnings and update their e-mail addresses and information to the DergiPark system. Otherwise, the e-mails from the journal will not be seen or fall into the SPAM folder. Please fill in all missing part in the relevant field.
Please visit journal's AUTHOR GUIDELINE to see revised policy and submission rules to be held since 2020.