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Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow

Year 2023, Volume: 7 Issue: 1, 108 - 112, 30.06.2023

Nazmiye Bitgen Özge Göktepe Münevver Baran Eren Kaan İpek Arzu Yay

https://doi.org/10.32571/ijct.1186924

Abstract

Nonylphenols are endocrine disrupting toxic compounds and are widely used. For this reason, our study aimed to investigate the genotoxic effect of nonylphenols applied at different doses on mouse bone marrow cells. Groups were classified as control group, the sham administered only group, low dose, medium dose and high dose nonylphenol administered group. After euthanasia, polychromatic erythrocyte/Normochromatic erythrocyte ratio and micronuclear polychromatic erythrocyte count were determined in femur bone marrow cells and analyzed to detect DNA damage. While polychromatic erythrocyte/Normochromatic erythrocyte ratio was found to be lower in the groups treated with different doses of nonylphenol, especially in the group treated with high-dose nonylphenol, this decrease was not statistically significant. When the micronucleated polychromatic erythrocyte values were examined, it was observed that there was a statistically significant increase, especially in the medium and high dose groups compared to the control. High-dose nonylphenol has a toxic effect and may have a long-term genotoxic effect such as cancer development by interacting with genotoxic agents.

Keywords

Nonylphenol genotoxicity micronucleus.

Supporting Institution

Erciyes University Scientific Research Projects Coordination Unit.

Project Number

TCD-2021-11459

References

  • Ozdemir, F.; Kayaaltı, Z.; Dilek, K. A. Marmara Pharm. J. 2015, 19(3), 246-251.
  • Zemheri, F.; Cevdet, U. Marmara Üniv. Fen Bilim. Derg. 2018, 30(1), 71-76.
  • Urriola-Muñoz, P.; Li, X.; Maretzky, T.; McIlwain, D.R.; Mak, T.W.; Reyes, J.G.; Blobel, C.P.; Moreno, D. J. Cell. Physiol. 2018, 233(3), 2247-2256.
  • Abou Khalil, N. S.; Abd‐Elkareem, M.; Sayed, A. H. Aquac. Nutr. 2017, 23(6), 1467-1474.
  • Dobrzyńska, M. M. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 2014, 772, 14-19.
  • Vazquez-Duhalt, R.; Marquez-Rocha, F.; Ponce, E.; Licea, A.F.; Vaiana, M.T. Appl. Ecol. Environ. Res. 2005, 4:1-25.
  • Wu, F.; Lin, L.; Qiu, J.W.; Chen, H.; Weng, S.; Luan, T. Aquat. Toxicol. 2014, 155, 43-51.
  • Shirdel, I.; Mohammad, R.K. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2016, 183-184, 28-35.
  • Fenech, M.; Chang, W. P.; Kirsch-Volders, M.; Holland, N.; Bonassi, S.; Zeiger, E. Mut. Res. 2003, 534, 65-75.
  • Baršienė, J.; Dedonytė, V.; Rybakovas, A.; Andreikėnaitė, L.; Andersen, O. K. Aquat. Toxicol. 2006, 78, 99-104.
  • Lambert, I.B.; Singer, T.M.; Boucher, S.E.; Douglas, G.R. Mutat. Res. 2005, 590, 1-280.
  • Mavourni, K.H.; Blakey, D.H.; Cimino, M.C.; Salamone, M.F.; Heddle, J.A. Mutat. Res. 1990, 239, 29-80.
  • Celik, A.; Mazmanci, B.; Camlica, Y.; Askin, A.; Comelekoglu, U. Mutat. Res. 2003, 539, 91-97.
  • Bara, M.; Bitgen, N.; Kalkan, K.T.; Goktepe, O.; Varol, S.; Yay, A.H. Dicle Tip Derg. 2022, 49(1), 36-44.
  • Aksu, P.; Doğan, A.; Gül, S.; Kanıcı, A. Kafkas Univ. Vet. Fak. Derg. 2013, 19(6), 955-961.
  • Mekkawy, I. A.; Mahmoud, U. M.; Sayed, A.H. Tissue and Cell. 2011, 43, 223-229.
  • Sharma, M.; Chadha, P. Drug Chem. Toxicol. 2017, 40(3), 320-325.

Year 2023, Volume: 7 Issue: 1, 108 - 112, 30.06.2023

Nazmiye Bitgen Özge Göktepe Münevver Baran Eren Kaan İpek Arzu Yay

https://doi.org/10.32571/ijct.1186924

Abstract

Project Number

TCD-2021-11459

References

  • Ozdemir, F.; Kayaaltı, Z.; Dilek, K. A. Marmara Pharm. J. 2015, 19(3), 246-251.
  • Zemheri, F.; Cevdet, U. Marmara Üniv. Fen Bilim. Derg. 2018, 30(1), 71-76.
  • Urriola-Muñoz, P.; Li, X.; Maretzky, T.; McIlwain, D.R.; Mak, T.W.; Reyes, J.G.; Blobel, C.P.; Moreno, D. J. Cell. Physiol. 2018, 233(3), 2247-2256.
  • Abou Khalil, N. S.; Abd‐Elkareem, M.; Sayed, A. H. Aquac. Nutr. 2017, 23(6), 1467-1474.
  • Dobrzyńska, M. M. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 2014, 772, 14-19.
  • Vazquez-Duhalt, R.; Marquez-Rocha, F.; Ponce, E.; Licea, A.F.; Vaiana, M.T. Appl. Ecol. Environ. Res. 2005, 4:1-25.
  • Wu, F.; Lin, L.; Qiu, J.W.; Chen, H.; Weng, S.; Luan, T. Aquat. Toxicol. 2014, 155, 43-51.
  • Shirdel, I.; Mohammad, R.K. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2016, 183-184, 28-35.
  • Fenech, M.; Chang, W. P.; Kirsch-Volders, M.; Holland, N.; Bonassi, S.; Zeiger, E. Mut. Res. 2003, 534, 65-75.
  • Baršienė, J.; Dedonytė, V.; Rybakovas, A.; Andreikėnaitė, L.; Andersen, O. K. Aquat. Toxicol. 2006, 78, 99-104.
  • Lambert, I.B.; Singer, T.M.; Boucher, S.E.; Douglas, G.R. Mutat. Res. 2005, 590, 1-280.
  • Mavourni, K.H.; Blakey, D.H.; Cimino, M.C.; Salamone, M.F.; Heddle, J.A. Mutat. Res. 1990, 239, 29-80.
  • Celik, A.; Mazmanci, B.; Camlica, Y.; Askin, A.; Comelekoglu, U. Mutat. Res. 2003, 539, 91-97.
  • Bara, M.; Bitgen, N.; Kalkan, K.T.; Goktepe, O.; Varol, S.; Yay, A.H. Dicle Tip Derg. 2022, 49(1), 36-44.
  • Aksu, P.; Doğan, A.; Gül, S.; Kanıcı, A. Kafkas Univ. Vet. Fak. Derg. 2013, 19(6), 955-961.
  • Mekkawy, I. A.; Mahmoud, U. M.; Sayed, A.H. Tissue and Cell. 2011, 43, 223-229.
  • Sharma, M.; Chadha, P. Drug Chem. Toxicol. 2017, 40(3), 320-325.
There are 17 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section Research Articles
Authors

Nazmiye Bitgen 0000-0002-6416-9230

Özge Göktepe 0000-0002-8205-2132

Münevver Baran 0000-0003-0369-1022

Eren Kaan İpek 0000-0002-8716-5347

Arzu Yay 0000-0001-8532-3543

Project Number TCD-2021-11459
Early Pub Date August 2, 2023
Publication Date June 30, 2023
Published in Issue Year 2023 Volume: 7 Issue: 1

Cite

APA Bitgen, N., Göktepe, Ö., Baran, M., İpek, E. K., et al. (2023). Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. International Journal of Chemistry and Technology, 7(1), 108-112. https://doi.org/10.32571/ijct.1186924
AMA Bitgen N, Göktepe Ö, Baran M, İpek EK, Yay A. Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. Int. J. Chem. Technol. June 2023;7(1):108-112. doi:10.32571/ijct.1186924
Chicago Bitgen, Nazmiye, Özge Göktepe, Münevver Baran, Eren Kaan İpek, and Arzu Yay. “Evaluation of the Genotoxic Effect of Nonylphenol Applied in Different Doses on the Bone Marrow”. International Journal of Chemistry and Technology 7, no. 1 (June 2023): 108-12. https://doi.org/10.32571/ijct.1186924.
EndNote Bitgen N, Göktepe Ö, Baran M, İpek EK, Yay A (June 1, 2023) Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. International Journal of Chemistry and Technology 7 1 108–112.
IEEE N. Bitgen, Ö. Göktepe, M. Baran, E. K. İpek, and A. Yay, “Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow”, Int. J. Chem. Technol., vol. 7, no. 1, pp. 108–112, 2023, doi: 10.32571/ijct.1186924.
ISNAD Bitgen, Nazmiye et al. “Evaluation of the Genotoxic Effect of Nonylphenol Applied in Different Doses on the Bone Marrow”. International Journal of Chemistry and Technology 7/1 (June 2023), 108-112. https://doi.org/10.32571/ijct.1186924.
JAMA Bitgen N, Göktepe Ö, Baran M, İpek EK, Yay A. Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. Int. J. Chem. Technol. 2023;7:108–112.
MLA Bitgen, Nazmiye et al. “Evaluation of the Genotoxic Effect of Nonylphenol Applied in Different Doses on the Bone Marrow”. International Journal of Chemistry and Technology, vol. 7, no. 1, 2023, pp. 108-12, doi:10.32571/ijct.1186924.
Vancouver Bitgen N, Göktepe Ö, Baran M, İpek EK, Yay A. Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. Int. J. Chem. Technol. 2023;7(1):108-12.
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