Abstract
Aim: To
investigate the effect of 25-hidroxy D vitamin, one of the environmental
factors, on recurrent wheezing episodes in pre-school children. Methods: This
research was conducted on77 patients who had recurrent wheezing attacks and were
followed by the pediatric allergy department of Keçiören Training and Research
Hospital, and other 74 healthy children attending the pediatric clinic with the
same age range as the control group.
charts of the patients and control group were reviewed to determine the weight, height, delivery method, their mother’s age, duration of vitamin D usage, nutrition history and
the time of the first wheezing attacks of the patient group, number of wheezing
attacks and the number of hospitalization due to the recurrent wheezing. Serum calcium, phosphorus, and 25-hidroxy
vitamin D and levels were evaluated in both groups. Results: Fifty-four
(70%) of the patient group were male and 23 (29.9%) of them were female. The
mean age was 29.5±17.9 months. Forty-four (59.5%) of the control group were
male and 30 (40.5%) of them were female. The mean age was 31.7±18.1
months. There was no relation between serum vitamin D levels, the date of first
wheezing attack, total number of wheezing attacks and number of
hospitalizations in the patient group. It was found that the number of wheezing
attacks of the patients with positive predictive index for asthma was
significantly higher than those with negative asthma predictive index but there
was no relation with serum 25-hydroxy vitamin D levels. Conclusions: In this research, no relation was found between serum
vitamin D levels and the date of first wheezing attack, total amount of
wheezing attacks and the number of hospitalizations due to these attacks.
Keywords
References
- 1. Sullivan SD. Asthma in the United States: recent trends and current status. J Manag Care Pharm. 2003; 9 Suppl 5: 3-7.
- 2. Braman SS. The global burden of asthma. Chest. 2006; 130 Suppl 1: 4S-12S.
- 3. Akinbami LJ, Schoendorf KC. Trends in childhood asthma: prevalence, health care utilization, and mortality. Pediatrics. 2002; 110: 315- 22)
- 4. Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: executive summary of The GINA Dissemination Committee report. Allergy 2004; 59(5):469-478.
- 5. Beasley R. The Global Burden of Asthma (GINA). Available from http//www.ginasthma.org 2004.
- 6. Yan DC, Ou LS, Tsai TL, Wu WF, Huang JL. Prevalence and severity of symptoms of asthma, rhinitis, and eczema in 13-to 14-year-old children in Taipei, Taiwan. Ann Allergy Asthma Immunol 2005; 95(6):579-585.
- 7.Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995; 332:133-8.
- 8.Wilson NM. The significance of early wheezing. ClinExp Allergy 1994; 24: 522-529.
- 9. Türktaş İ, Selçuk ZT, Kalyoncu AF. Prevalance of asthma and wheezing in Turkish children. World Asthma Meeting. 9-13 Aralık1998 Barselona/ İspanya. EurRespir J 1998 ; (Suppl 29): 52. )
- 10.Moss M, Gern J, Lemanske R, Asthma in infancy and childhood, in Middletton’s Allergy Principles & Practice. 2003, Mosby.p. 1225.
- 11- Karmaus W, Botezan C. Does a higher number of siblingsprotect against the development of allergy and asthma? Areview. J Epidemiol Community Health 2002;56:209-217.
- 12-Aytemur Solak Z. Astım ve Atopi gelişiminde Hijyen Hipotezi, Toraks Dergisi, 4;3; Aralık 2003.
- 13. Mason RS, Sequeira VB, Gordon-Thomson C.Vitamin D: the light side of sunshine.Eur J Clin Nutr. 2011; 65 : 986-93. doi: 10.1038 / ejcn.2011.105
- 14. Tang J, Zhou R, Luger D, Zhu W, Silver PB, Grajewski RS ve diğ. Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J Immunol. 2009 Apr 15;182(8):4624-32. doi: 10.4049/jimmunol.0801543.
- 15. Pichler J, Gerstmayr M, Szépfalusi Z, Urbanek R, Peterlik M, Willheim M. 1 alpha,25(OH)2D3 inhibits not only Th1 but also Th2 differentiation in human cord blood T cells. Pediatr Res. 2002 Jul;52(1):12-8.
- 16. Matheu V, Bäck O, Mondoc E, Issazadeh-Navikas S. Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease. J Allergy Clin Immunol. 2003 Sep;112(3):585-92).
- 17. Gombart AF, Borregaard N, Koeffler HP.Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3.FASEB J. 2005 Jul;19(9):1067-77.
- 18. Wang TT, Tavera-Mendoza LE, Laperriere D, Libby E, MacLeod NB, Nagai Y ve diğ. Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes.Mol Endocrinol. 2005 Nov;19(11):2685-95. Epub 2005 Jul 7.
- 19. Castro-Rodriguez JA, Holberg CJ, Wright AL, Martinez FD. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000;162(4 pt 1):1403-6.
- 20.Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics 2008 Aug;122(2):398-417.
- 21.Ginde AA, Mansbach JM, Camargo CA. Vitamin D, respiratory infections, and asthma.Curr Allergy Asthma Rep. 2009 Jan;9(1):81-7.
- 22.Litonjua AA1, Weiss ST.Is vitamin D deficiency to blame for the asthma epidemic?J Allergy Clin Immunol. 2007 Nov;120(5):1031-5. Epub 2007 Oct 24.
- 23.Freishtat RJ, Iqbal SF, Pillai DK, Klein CJ, Ryan LM, Benton AS, Teach SJ. High prevalence of vitamin D deficiency among inner-city African American youth with asthma in Washington, DC, J. Pediatr. 2010; 156:948-952.
- 24. Devereux G, Wilson A, Avenell A, McNeill G, Fraser WD. A caseecontrol study of vitamin D status and asthma in adults, Allergy 2010; 65:666-667.
- 25.Roth DE, Jones AB, Prosser C, Robinson JL, Vohra S. Vitamin D status is not associated with the risk of hospitalization for acute bronchiolitis in early childhood, Eur. J. Clin. Nutr. 2009; 63: 297-299.
- 26.Dell S, To T. Breastfeeding and asthma in young children. Arch Pediatr Adolesc Med. 2001;155:1261-5.
- 27.Kramer MS, Matush L, Vanilovich I, Platt R, Bogdanovich N, sevkovskaya Z, Dzikovich, Shishko G, Mazer B, PROBIT study group. Effect of prolonged and exclusive breastfeeding on risk of allergy and asthma: cluster randomised trial. BMJ 2007; 335;815-21
Okul öncesi çocuklarda serum 25-hidroksi D vitamin düzeyleri ile tekrarlayan hışıltı arasındaki ilişki
Abstract
Amaç: Çevresel faktörlerden biri olan 25-hidroksi D
vitamininin okul öncesi çocuklarda tekrarlayan hışıltı ataklarına etkisini
araştırmak. Yöntem: Çalışmaya
Keçiören Eğitim ve Araştırma Hastanesi Çocuk Alerji Polikliniği’nde tekrarlayan
vizing atağı nedeni ile takipli 77 hasta, kontrol grubuna benzer yaş grubunda
olan çocuk sağlığı polikliniğine başvuran 74 sağlıklı çocuk alındı. Hasta ve
kontrol grubunun dosyaları incelenerek çocukların ağırlık, boy, doğum şekli,
anne yaşı, D vitamini kullanma süresi, beslenme öyküsü ve ayrıca hasta
grubundakilerin ilk vizing atak zamanı, vizing atak sayısı ve vizing nedeniyle
hastaneye yatış sayısı belirlendi. Her iki grupta serum kalsiyum, fosfor ve
25-Hidroksi D vitamini düzeyleri çalışıldı. Bulgular: Hasta grubunun 54’ü (%70.1) erkek, 23’ü
(%29.9) kız, ortalama yaşları 29.5±1.9 ay olup kontrol grubunun 44’ü
(%59.5) erkek, 30’u (%40.5) kız ve ortalama
yaşları 31.7±18.1 aydı. Hasta grubunda serum D vitamini düzeyi ile ilk
vizing atak zamanı, vizing atak sayısı ve hastaneye yatış sayıları arasında bir
ilişki bulunmadı. Hasta grupta astım prediktif indeksi pozitif olanların vizing
atak sayısının negatif olan gruptan anlamlı olarak daha fazla olduğu ancak serum 25
hidroksi vitamin D vitamini düzeyi ile arasında
ilişki olmadığı saptandı. Sonuç: Çalışmamızda serum D vitamini düzeyi ile ilk vizing atak zamanı,
vizing atak sayısı ve hastaneye yatış sayısı arasında ilişki saptanmamıştır.
References
- 1. Sullivan SD. Asthma in the United States: recent trends and current status. J Manag Care Pharm. 2003; 9 Suppl 5: 3-7.
- 2. Braman SS. The global burden of asthma. Chest. 2006; 130 Suppl 1: 4S-12S.
- 3. Akinbami LJ, Schoendorf KC. Trends in childhood asthma: prevalence, health care utilization, and mortality. Pediatrics. 2002; 110: 315- 22)
- 4. Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: executive summary of The GINA Dissemination Committee report. Allergy 2004; 59(5):469-478.
- 5. Beasley R. The Global Burden of Asthma (GINA). Available from http//www.ginasthma.org 2004.
- 6. Yan DC, Ou LS, Tsai TL, Wu WF, Huang JL. Prevalence and severity of symptoms of asthma, rhinitis, and eczema in 13-to 14-year-old children in Taipei, Taiwan. Ann Allergy Asthma Immunol 2005; 95(6):579-585.
- 7.Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995; 332:133-8.
- 8.Wilson NM. The significance of early wheezing. ClinExp Allergy 1994; 24: 522-529.
- 9. Türktaş İ, Selçuk ZT, Kalyoncu AF. Prevalance of asthma and wheezing in Turkish children. World Asthma Meeting. 9-13 Aralık1998 Barselona/ İspanya. EurRespir J 1998 ; (Suppl 29): 52. )
- 10.Moss M, Gern J, Lemanske R, Asthma in infancy and childhood, in Middletton’s Allergy Principles & Practice. 2003, Mosby.p. 1225.
- 11- Karmaus W, Botezan C. Does a higher number of siblingsprotect against the development of allergy and asthma? Areview. J Epidemiol Community Health 2002;56:209-217.
- 12-Aytemur Solak Z. Astım ve Atopi gelişiminde Hijyen Hipotezi, Toraks Dergisi, 4;3; Aralık 2003.
- 13. Mason RS, Sequeira VB, Gordon-Thomson C.Vitamin D: the light side of sunshine.Eur J Clin Nutr. 2011; 65 : 986-93. doi: 10.1038 / ejcn.2011.105
- 14. Tang J, Zhou R, Luger D, Zhu W, Silver PB, Grajewski RS ve diğ. Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J Immunol. 2009 Apr 15;182(8):4624-32. doi: 10.4049/jimmunol.0801543.
- 15. Pichler J, Gerstmayr M, Szépfalusi Z, Urbanek R, Peterlik M, Willheim M. 1 alpha,25(OH)2D3 inhibits not only Th1 but also Th2 differentiation in human cord blood T cells. Pediatr Res. 2002 Jul;52(1):12-8.
- 16. Matheu V, Bäck O, Mondoc E, Issazadeh-Navikas S. Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease. J Allergy Clin Immunol. 2003 Sep;112(3):585-92).
- 17. Gombart AF, Borregaard N, Koeffler HP.Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3.FASEB J. 2005 Jul;19(9):1067-77.
- 18. Wang TT, Tavera-Mendoza LE, Laperriere D, Libby E, MacLeod NB, Nagai Y ve diğ. Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes.Mol Endocrinol. 2005 Nov;19(11):2685-95. Epub 2005 Jul 7.
- 19. Castro-Rodriguez JA, Holberg CJ, Wright AL, Martinez FD. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000;162(4 pt 1):1403-6.
- 20.Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics 2008 Aug;122(2):398-417.
- 21.Ginde AA, Mansbach JM, Camargo CA. Vitamin D, respiratory infections, and asthma.Curr Allergy Asthma Rep. 2009 Jan;9(1):81-7.
- 22.Litonjua AA1, Weiss ST.Is vitamin D deficiency to blame for the asthma epidemic?J Allergy Clin Immunol. 2007 Nov;120(5):1031-5. Epub 2007 Oct 24.
- 23.Freishtat RJ, Iqbal SF, Pillai DK, Klein CJ, Ryan LM, Benton AS, Teach SJ. High prevalence of vitamin D deficiency among inner-city African American youth with asthma in Washington, DC, J. Pediatr. 2010; 156:948-952.
- 24. Devereux G, Wilson A, Avenell A, McNeill G, Fraser WD. A caseecontrol study of vitamin D status and asthma in adults, Allergy 2010; 65:666-667.
- 25.Roth DE, Jones AB, Prosser C, Robinson JL, Vohra S. Vitamin D status is not associated with the risk of hospitalization for acute bronchiolitis in early childhood, Eur. J. Clin. Nutr. 2009; 63: 297-299.
- 26.Dell S, To T. Breastfeeding and asthma in young children. Arch Pediatr Adolesc Med. 2001;155:1261-5.
- 27.Kramer MS, Matush L, Vanilovich I, Platt R, Bogdanovich N, sevkovskaya Z, Dzikovich, Shishko G, Mazer B, PROBIT study group. Effect of prolonged and exclusive breastfeeding on risk of allergy and asthma: cluster randomised trial. BMJ 2007; 335;815-21
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Articles |
| Authors | |
| Publication Date | April 28, 2019 |
| Submission Date | June 29, 2018 |
| Acceptance Date | December 17, 2018 |
| Published in Issue | Year 2019 Volume: 12 Issue: 1 |
Cite
MEU Journal of Health Sciences Assoc was began to the publishing process in 2008 under the supervision of Assoc. Prof. Gönül Aslan, Editor-in-Chief, and affiliated to Mersin University Institute of Health Sciences. In March 2015, Prof. Dr. Caferi Tayyar Şaşmaz undertook the Editor-in Chief position and since then he has been in charge.
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