Abstract
Bu
çalışmada farklı geometrideki mikrokanallar içerisinde saf su akışı için elde
edilen cidar kayma gerilmesi ve basınç farkı değerleri sayısal olarak elde
edilmiştir. Çalışma, benzer bir laboratuvar ortamında farklı debilerde endotel
ve immun sistem hücreleri üzerinde meydana gelebilecek farklı fiziksel etkileri
ve bu hücrelerin davranışlarını inceleyebilmek için bir ön çalışma
niteliğindedir. Belirlenen debi aralığında, endotel hücrelerinin ve monosit
hücrelerinin in-vivo’da fizyolojik olarak maruz kaldıkları ya da
kalabilecekleri alt ve üst cidar kayma gerilmesi değerleri sayısal olarak
tahmin edilmeye çalışılmıştır. Bu kapsamda; farklı genişleme oranlarına sahip
ani genişlemeli mikro- kanallar, bir cidarı kaviteli ve simetrik kıvrımlı mikrokanal
olarak adlandırılan üç değişik konfigürasyonda ve farklı hacimsel debi değerlerinde
analizler yapılarak, mikrokanal alt cidarlarında meydana gelen kayma gerilmesi
değerleri ve kanal girişi ile çıkışı arasında oluşan basınç farkı değerleri
sayısal olarak elde edilmiştir.
Keywords
Mikrokanal akışı Hesaplamalı Akışkanlar Dinamiği (HAD) Mekano-biyolojik davranış Cidar kayma gerilmesi
References
- Demir U. Mikrokanallarda Basınç Düşümü, Cidar Kayma Gerilmesi ve Partikül Fokuslanmasının Sayısal Olarak İncelenmesi. Yüksek Lisans Tezi, İstanbul Teknik Üniversitesi, İstanbul, Türkiye, 2015.
- Verpoorte E, De Rooij NF. “Microfluidics meets MEMS”. Proceedings of the IEEE, 91(6), 930-953, 2003.
- McDonald JC, Duffy DC, Anderson JR, Chiu DT, Wu H, Schueller OJ, Whitesides GM. “Fabrication of microfluidic systems in polydimethylsiloxane. Electrophoresis, 21(1), 27-40, 2000.
- Chang W, Trebotich D, Lee LP, Liepmann D. “Blood flow in simple microchannels”. 1st Annual international IEEE-EMBS Special Topic Conference on Micro-Technologies in Medicine and Biology, Lyon, France, 12-14 October 2000.
- Sharma K, Müller N, Selerowicz W. “Experimental friction factor study for microchannel flows”. 6th International Workshop on Micro and Nano Technology for Power Generation and Energy Conversion Applications, Berkeley, USA, 29 November-1 December 2006.
- Gunnasegaran P, Mohammed H, Shuaib NH. “Pressure drop and friction factor for different shapes of micro-channels’’. 3rd International Conference on Energy and Environment, Malakka, Malaysia, 7-8 December 2009.
- Hrnjak P, Tu X. “Single phase pressure drop in microchannels”. International Journal of Heat and Fluid Flow, 28(1), 2-14, 2007.
- Bahrami M, Yovanovich M, Culham JR. “Pressure drop of fully developed laminar flow in microchannel of arbitrary cross section”. 3rd International Conference on Microchannels and Minichannels, Toronto, Canada, 13-15 June 2005.
- Rossi M, Westerweel J, Ekeberg I, Vennemann P. “In vitro study of shear stress over endothelial cells by micro particle image velocimetry”. 13th International Symposium on Applications of Laser Techniques to Fluid Mechanics, Lisbon, Portugal, 26-29 June 2006.
- Tian WC, Finehout E. Microfluidics for Biological Applications. 1st ed. Michigan, USA, Springer Science and Business Media, 2009.
- Davies PF. “Flow-mediated endothelial mechano-transduction”. Physiological Reviews, 75(3), 519-560, 1995.
- Song JW, Gu W, Futai N, Warner KA, Nor JE, Takayama S. “Computer controlled microcirculatory support system for endothelial cell culture and shearing”. Analytical Chemistry, 77(13), 3993-3999, 2005
- Lehoux S, Castier Y, Tedgui A. “Molecular mechanisms of the vascular responses to haemodynamic forces”. Journal of Internal Medicine, 259(4), 381-392, 2006.
- Chang WC, Lee LP, Liepmann D. “Biomimetic technique for adhesion based collection and separation of cells in a microfluidic channel”. Lab Chip, 5(1), 64-73, 2005.
- Lu H, Koo LY, Jensen KF, Wang WM. “Microfluidic shear devices for quantitive analysis of cell adhesion”. Analytical Chemistry, 76, 5257-5264,2004.
- Paszkowiak JJ, Dardik A. “Arterial wall shear stress: observations from the bench to the bedside”. Vascular and Endovascular Surgery, 37(1), 47-57, 2003.
- Kwak B.R., Bäck M., Bochaton-Piallat M.L., Caligiuri G., Daemen M.J.A.P., Davies P.F., Hoefer I.E., Holvoet P., Jo H., Krams R., Lehoux S., Monaco C., Steffens S.,Virmani R., Weber C., Wentzel J. J., Evans P. C. “Biomechanical factors in atherosclerosis: Mechanisms and clinical implications”. European Heart Journal, 35(43), 3013-3020, 2014.
- Cunningham KS, Gotlieb AI. “The role of shear stress in the pathogenesis of atherosclerosis”. Laboratory Investigation, 85(1), 9-23, 2005.
Abstract
In
this study, wall shear stress and pressure difference values for a pure water
flow in various microchannel configurations are obtained numerically. Through
simulations, physical effects of various flow rates on endothelium and immune
system cells are predicted and case studies are carried out to investigate the
behavior of such cells under similar laboratory conditions. In-vivo
physiological behavior of endothelium and monocyte cells under real conditions
can be predicted by pressure differences and wall shear stresses calculated for
various flowrates. In this concept, various microchannel configurations such as
sudden expanding microchannels with different expansion ratios, microchannels
with cavities on one side and symmetrically curved microchannels are designed
and CFD simulations are carried out to obtain computational values of the
pressure drops between the inlet and outlet of the microchannels as well as
wall shear stress distributions on the bottom walls of the configurations.
Keywords
Microchannel flows Computational Fluid Dynamics (CFD) Mechano-biological behavior Wall shear stress
References
- Demir U. Mikrokanallarda Basınç Düşümü, Cidar Kayma Gerilmesi ve Partikül Fokuslanmasının Sayısal Olarak İncelenmesi. Yüksek Lisans Tezi, İstanbul Teknik Üniversitesi, İstanbul, Türkiye, 2015.
- Verpoorte E, De Rooij NF. “Microfluidics meets MEMS”. Proceedings of the IEEE, 91(6), 930-953, 2003.
- McDonald JC, Duffy DC, Anderson JR, Chiu DT, Wu H, Schueller OJ, Whitesides GM. “Fabrication of microfluidic systems in polydimethylsiloxane. Electrophoresis, 21(1), 27-40, 2000.
- Chang W, Trebotich D, Lee LP, Liepmann D. “Blood flow in simple microchannels”. 1st Annual international IEEE-EMBS Special Topic Conference on Micro-Technologies in Medicine and Biology, Lyon, France, 12-14 October 2000.
- Sharma K, Müller N, Selerowicz W. “Experimental friction factor study for microchannel flows”. 6th International Workshop on Micro and Nano Technology for Power Generation and Energy Conversion Applications, Berkeley, USA, 29 November-1 December 2006.
- Gunnasegaran P, Mohammed H, Shuaib NH. “Pressure drop and friction factor for different shapes of micro-channels’’. 3rd International Conference on Energy and Environment, Malakka, Malaysia, 7-8 December 2009.
- Hrnjak P, Tu X. “Single phase pressure drop in microchannels”. International Journal of Heat and Fluid Flow, 28(1), 2-14, 2007.
- Bahrami M, Yovanovich M, Culham JR. “Pressure drop of fully developed laminar flow in microchannel of arbitrary cross section”. 3rd International Conference on Microchannels and Minichannels, Toronto, Canada, 13-15 June 2005.
- Rossi M, Westerweel J, Ekeberg I, Vennemann P. “In vitro study of shear stress over endothelial cells by micro particle image velocimetry”. 13th International Symposium on Applications of Laser Techniques to Fluid Mechanics, Lisbon, Portugal, 26-29 June 2006.
- Tian WC, Finehout E. Microfluidics for Biological Applications. 1st ed. Michigan, USA, Springer Science and Business Media, 2009.
- Davies PF. “Flow-mediated endothelial mechano-transduction”. Physiological Reviews, 75(3), 519-560, 1995.
- Song JW, Gu W, Futai N, Warner KA, Nor JE, Takayama S. “Computer controlled microcirculatory support system for endothelial cell culture and shearing”. Analytical Chemistry, 77(13), 3993-3999, 2005
- Lehoux S, Castier Y, Tedgui A. “Molecular mechanisms of the vascular responses to haemodynamic forces”. Journal of Internal Medicine, 259(4), 381-392, 2006.
- Chang WC, Lee LP, Liepmann D. “Biomimetic technique for adhesion based collection and separation of cells in a microfluidic channel”. Lab Chip, 5(1), 64-73, 2005.
- Lu H, Koo LY, Jensen KF, Wang WM. “Microfluidic shear devices for quantitive analysis of cell adhesion”. Analytical Chemistry, 76, 5257-5264,2004.
- Paszkowiak JJ, Dardik A. “Arterial wall shear stress: observations from the bench to the bedside”. Vascular and Endovascular Surgery, 37(1), 47-57, 2003.
- Kwak B.R., Bäck M., Bochaton-Piallat M.L., Caligiuri G., Daemen M.J.A.P., Davies P.F., Hoefer I.E., Holvoet P., Jo H., Krams R., Lehoux S., Monaco C., Steffens S.,Virmani R., Weber C., Wentzel J. J., Evans P. C. “Biomechanical factors in atherosclerosis: Mechanisms and clinical implications”. European Heart Journal, 35(43), 3013-3020, 2014.
- Cunningham KS, Gotlieb AI. “The role of shear stress in the pathogenesis of atherosclerosis”. Laboratory Investigation, 85(1), 9-23, 2005.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Engineering |
| Journal Section | Research Article |
| Authors | |
| Publication Date | February 27, 2018 |
| Published in Issue | Year 2018 Volume: 24 Issue: 1 |
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