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KESTANE BALINDAN SENTEZLENEN KARBON NOKTALARIN TETRASİKLİN ANALİZİNDE KULLANILABİLİRLİĞİNİN ARAŞTIRILMASI

Year 2017, Volume: 17 Issue: 2, 49 - 58, 30.11.2017

SALİHA Dinç

https://doi.org/10.31467/uluaricilik.372241

Abstract

Dünya için bir tehdit olan antibiyotik direncinin önüne geçme yollarından birisi de gıdalarda bulunan

antibiyotik kalıntılarını önlemektir. Ülkemizde antibiyotik kalıntıları et, süt, bal, yumurta gibi

hayvansal gıdalarda bulunmaktadır. Antibiyotik kalıntılarının hızlı, basit ve ucuz yöntemlerle tespiti

gıdalarda ki antibiyotik kalıntılarını izlemeyi kolaylaştıracaktır. Karbon noktalar 10 nm’den küçük

nanopartiküller olup analitik çalışmalarda yararlanılmaktadır. Floresans özellikleri, suda çözünür

olmaları ve toksik olmamaları karbon noktaların üstün özelliklerinden bazılarıdır. Bu çalışmada balda

en çok rastlanan tetrasiklinin hızlı tayini için karbon noktalar kullanılmıştır. Karbon noktalar, kestane

balından herhangi bir kimyasal kullanılmadan mikrodalga yöntemi ile sentezlenmiştir. UV ışık altında

mavi floresans veren karbon noktaların emisyon şiddetindeki azalma (sönümleme) esas alınarak

tetrasiklin analizi yapılmıştır. Artan tetrasiklin konsantrasyonlarına karşı artan sönümleme miktarları

grafiğe geçirilerek kalibrasyon doğrusu elde edilmiştir. Korelasyon katsayısı (R2) 0.99 olarak

hesaplanmıştır Tetrasiklin analizi başarı ile yapılmış ancak geliştirilen yöntemin gıda

numunelerindeki uygulamasının yapılması gerekmektedir.

Keywords

Karbon noktalar Tetrasiklin Kestane Balı Antibiyotik kalıntısı Nanoteknoloji

References

  • Algar, W. R.,Tavares, A.J., Krull, U.J.(2010) Beyond labels: A review of the application of quantum dots as integrated components of assays, bioprobes, and biosensors utilizing optical transduction. Analytica Chimica Acta. 673:1-25
  • Baker, S.N., Baker, G.A. (2010).Luminescent carbon nanodots: Emergent nanolights. Angew. Chem. Int. 49: 6726–6744
  • Çetin, K., Alkın, E., Uçurum, H.Ö. (2011). Piyasada satılan çiçek ballarının kalite kriterlerinin belirlenmesi. Journal of Food and Feed Science – Technology.11:49-56
  • Dinç, S. (2016). A simple and green extraction of carbon dots from sugar beet molasses: Biosensor applications. Sugar Industry 141: No. 9: 560–564
  • Dinç, S., Kara, M., Kars, M.D., Aykül, F., Çiçekci, H., Akkuş, M. (2017). Biocompatible yoğurt carbon dots: evaluation of utilization for medical applications .Applied Physics A.123:572. doi:10.1007/s00339-017-1184-y
  • Drbohlavova, J., Adam, V., Kizek, R. and Hubalek, J. (2009). Quantum Dots — Characterization, Preparation and Usage in Biological Systems. Int. J. Mol. Sci. 10: 656-673; doi:10.3390/ijms10020656
  • Durmuşoğlu, E.G. (2017). Kuantum Nokta. https://www.metalurji.org.tr/dergi/dergi160/d160_3134.pdf
  • Essner, J.B.,Laber, H.C., Ravula, S., Polo-Parada, L. and Baker, G.A. (2016). Pee-dots: biocompatible fluorescent carbon dots derived from the upcycling of urine. GreenChem. 18:243-250
  • Feng, Y.,Zhong, D.,Miao, H.,Yang, X. (2015). Carbon dots derived from rose flowers for tetracycline sensing. Talanta. 140: 128–133
  • Himaja, A.L.,Karthik, P.S., Sreedhar, B., Singh, S.P. (2014). Synthesis of Carbon Dots from Kitchen Waste: Conversion of Waste to Value Added Product. Journal of Fluorescence. 24(6):1767-1773
  • Hu, C.,Yu, C., Li, M., Wang, X., Yang, J., Zhao, Z., Eychmüller, A., Sun, Y.-P. and Qiu, J. (2014), Chemically Tailoring Coal to Fluorescent Carbon Dots with Tuned Size and Their Capacity for Cu(II) Detection. Small, 10: 4926–4933. doi:10.1002/smll.201401328
  • Kara, M., Uzun, L., Kolaylı , S., Denizli, A. (2012) Combining molecular imprinted nanoparticles with surface plasmon resonance nanosensor for chloramphenicol detection in honey. J. Appl. Polym. Sci. doi: 10.1002/APP.38936 1
  • Karaçağlar, N.N. (2017) Antibiyotik tayinine yönelik biyosensör geliştirilmesi. Hacettepe Üniversitesi Fen Bilimleri Enstitüsü Yayınlanmış Doktora Tezi, Ankara
  • Lim, S.Y.,Shen, W. and Gao, Z. (2014). Carbon quantum dots and their applications. Chem. Soc.Rev. doi: 10.1039/c4cs00269e
  • Mandani, S.,Dey, D., Sharma, B., Sarma, T.K. (2017). Natural occurrence of fluorescent carbon dots in honey..Carbon. doi: 10.1016/j.carbon.2017.04.075
  • Nisha, A.R. (2008). Antibiotic Residues - A Global Health Hazard. Veterinary World. 1(12): 375-377
  • Özkan, O., Eşsiz, D., Yazıcı, K., Erdağ D. (2015). Ardahan İlinde Üretilen Ballarda Antibiyotik Kalıntı Düzeylerinin Araştırılması. Atatürk Üniversitesi Vet. Bil. Derg. 10(2): 88-92
  • Pisanic, T.R., Zhang, Y. And Wang, T.H. (2014). Quantum dots in diagnostics and detection: principles and paradigms. Analyst. 139: 2968-2981
  • Sarıkaya, A.O., Ulusoy, E., Oztürk, N., Tunçel, M. ve Kolaylı, S. (2009) Antioxidant activity and phenolic acid constituents of chestnut (Castania sativa mill.) honey and propolis. J. Food Biochem. 33: 470–481.
  • Seğmenoğlu, M.S. ve Baydan E. (2012). Ballarda Rastlanabilen İlaç Kalıntıları ve Bulaşanlar. AVKAE Derg. 2: 24-28 She, P.,Chu, Y., Liu, C., Guo, X., Zhao, K.,Li, J.,Du,H., Zhang, X., Wang, H.,Deng, A. (2016). A competitive immunoassay for ultrasensitive detection of Hg2+ in water, human serum and urine samples using immunochromatographic test based on surface-enhanced Raman scattering. Analytica Chimica Acta.906: 139–147
  • Shen, L-M.,Jing, L. (2016). New development in carbon quantum dots technical applications. Talanta. 156-157:245–256
  • Shi, W., Wang, Q., Long, Y., Cheng, Z., Chen, S., Zheng, H., Huang, Y. (2011). Carbon nanodots as peroxidase mimetics and their applications to glucose detection. Chem. Commun. 47: 6695–6697
  • Sk, M.P., Jaiswal, A., Paul, A., Ghosh, S.S., Chattopadhyay, A. (2012). Presence of amorphous carbon nanoparticles in food caramels. Scientific Reports.383 (2): 1–5
  • Sunay, A.E. (2006). Balda antibiyotik kalıntısı sorunu. Uludag Bee Journal. November. 143-148
  • Tan, H., Li, Q., Zhou, Z., Ma, C., Song, Y., Xu, F., Wang L. (2015). A sensitive fluorescent assay for thiamine based on metal-organic frameworks with intrinsic peroxidase-like activity. Analytica Chimica Acta. 856: 90–95.
  • Wu, L., Cai, X., Nelson, K., Xing, W., Xia, J., Zhang, R., Stacy, A.J, Luderer, M., Lanza, G.M., Wang, L.V., Shen, B., Pan, D. (2013). A green synthesis of carbon nanoparticles from honey and their use in real-time photoacoustic imaging. Nano Research. 6(5): 312–325. doi:10.1007/s12274-013-0308-8.
  • Yang, X., Zhuo, Y., Zhu, S., Luo, Y., Feng, Y., Dou, Y. (2014). Novel and green synthesis of high-fluorescent carbon dots originated from honey for sensing and imaging. Biosensors and Bioelectronics. 60: 292–298.
  • Yıbar, A., Soyutemiz, E. (2013). Gıda değeri olan hayvanlarda antibiyotik kullanımı ve muhtemel kalıntı riski. Atatürk Üniversitesi Vet. Bil. Derg. 8(1): 97-104.
  • Yu, W.W., Chang, E., Drezek, R., Colvin, V.L. (2006). Water-soluble quantum dots for biomedical applications. Biochemical and Biophysical Research Communications. 348: 781–786

Year 2017, Volume: 17 Issue: 2, 49 - 58, 30.11.2017

SALİHA Dinç

https://doi.org/10.31467/uluaricilik.372241

Abstract

References

  • Algar, W. R.,Tavares, A.J., Krull, U.J.(2010) Beyond labels: A review of the application of quantum dots as integrated components of assays, bioprobes, and biosensors utilizing optical transduction. Analytica Chimica Acta. 673:1-25
  • Baker, S.N., Baker, G.A. (2010).Luminescent carbon nanodots: Emergent nanolights. Angew. Chem. Int. 49: 6726–6744
  • Çetin, K., Alkın, E., Uçurum, H.Ö. (2011). Piyasada satılan çiçek ballarının kalite kriterlerinin belirlenmesi. Journal of Food and Feed Science – Technology.11:49-56
  • Dinç, S. (2016). A simple and green extraction of carbon dots from sugar beet molasses: Biosensor applications. Sugar Industry 141: No. 9: 560–564
  • Dinç, S., Kara, M., Kars, M.D., Aykül, F., Çiçekci, H., Akkuş, M. (2017). Biocompatible yoğurt carbon dots: evaluation of utilization for medical applications .Applied Physics A.123:572. doi:10.1007/s00339-017-1184-y
  • Drbohlavova, J., Adam, V., Kizek, R. and Hubalek, J. (2009). Quantum Dots — Characterization, Preparation and Usage in Biological Systems. Int. J. Mol. Sci. 10: 656-673; doi:10.3390/ijms10020656
  • Durmuşoğlu, E.G. (2017). Kuantum Nokta. https://www.metalurji.org.tr/dergi/dergi160/d160_3134.pdf
  • Essner, J.B.,Laber, H.C., Ravula, S., Polo-Parada, L. and Baker, G.A. (2016). Pee-dots: biocompatible fluorescent carbon dots derived from the upcycling of urine. GreenChem. 18:243-250
  • Feng, Y.,Zhong, D.,Miao, H.,Yang, X. (2015). Carbon dots derived from rose flowers for tetracycline sensing. Talanta. 140: 128–133
  • Himaja, A.L.,Karthik, P.S., Sreedhar, B., Singh, S.P. (2014). Synthesis of Carbon Dots from Kitchen Waste: Conversion of Waste to Value Added Product. Journal of Fluorescence. 24(6):1767-1773
  • Hu, C.,Yu, C., Li, M., Wang, X., Yang, J., Zhao, Z., Eychmüller, A., Sun, Y.-P. and Qiu, J. (2014), Chemically Tailoring Coal to Fluorescent Carbon Dots with Tuned Size and Their Capacity for Cu(II) Detection. Small, 10: 4926–4933. doi:10.1002/smll.201401328
  • Kara, M., Uzun, L., Kolaylı , S., Denizli, A. (2012) Combining molecular imprinted nanoparticles with surface plasmon resonance nanosensor for chloramphenicol detection in honey. J. Appl. Polym. Sci. doi: 10.1002/APP.38936 1
  • Karaçağlar, N.N. (2017) Antibiyotik tayinine yönelik biyosensör geliştirilmesi. Hacettepe Üniversitesi Fen Bilimleri Enstitüsü Yayınlanmış Doktora Tezi, Ankara
  • Lim, S.Y.,Shen, W. and Gao, Z. (2014). Carbon quantum dots and their applications. Chem. Soc.Rev. doi: 10.1039/c4cs00269e
  • Mandani, S.,Dey, D., Sharma, B., Sarma, T.K. (2017). Natural occurrence of fluorescent carbon dots in honey..Carbon. doi: 10.1016/j.carbon.2017.04.075
  • Nisha, A.R. (2008). Antibiotic Residues - A Global Health Hazard. Veterinary World. 1(12): 375-377
  • Özkan, O., Eşsiz, D., Yazıcı, K., Erdağ D. (2015). Ardahan İlinde Üretilen Ballarda Antibiyotik Kalıntı Düzeylerinin Araştırılması. Atatürk Üniversitesi Vet. Bil. Derg. 10(2): 88-92
  • Pisanic, T.R., Zhang, Y. And Wang, T.H. (2014). Quantum dots in diagnostics and detection: principles and paradigms. Analyst. 139: 2968-2981
  • Sarıkaya, A.O., Ulusoy, E., Oztürk, N., Tunçel, M. ve Kolaylı, S. (2009) Antioxidant activity and phenolic acid constituents of chestnut (Castania sativa mill.) honey and propolis. J. Food Biochem. 33: 470–481.
  • Seğmenoğlu, M.S. ve Baydan E. (2012). Ballarda Rastlanabilen İlaç Kalıntıları ve Bulaşanlar. AVKAE Derg. 2: 24-28 She, P.,Chu, Y., Liu, C., Guo, X., Zhao, K.,Li, J.,Du,H., Zhang, X., Wang, H.,Deng, A. (2016). A competitive immunoassay for ultrasensitive detection of Hg2+ in water, human serum and urine samples using immunochromatographic test based on surface-enhanced Raman scattering. Analytica Chimica Acta.906: 139–147
  • Shen, L-M.,Jing, L. (2016). New development in carbon quantum dots technical applications. Talanta. 156-157:245–256
  • Shi, W., Wang, Q., Long, Y., Cheng, Z., Chen, S., Zheng, H., Huang, Y. (2011). Carbon nanodots as peroxidase mimetics and their applications to glucose detection. Chem. Commun. 47: 6695–6697
  • Sk, M.P., Jaiswal, A., Paul, A., Ghosh, S.S., Chattopadhyay, A. (2012). Presence of amorphous carbon nanoparticles in food caramels. Scientific Reports.383 (2): 1–5
  • Sunay, A.E. (2006). Balda antibiyotik kalıntısı sorunu. Uludag Bee Journal. November. 143-148
  • Tan, H., Li, Q., Zhou, Z., Ma, C., Song, Y., Xu, F., Wang L. (2015). A sensitive fluorescent assay for thiamine based on metal-organic frameworks with intrinsic peroxidase-like activity. Analytica Chimica Acta. 856: 90–95.
  • Wu, L., Cai, X., Nelson, K., Xing, W., Xia, J., Zhang, R., Stacy, A.J, Luderer, M., Lanza, G.M., Wang, L.V., Shen, B., Pan, D. (2013). A green synthesis of carbon nanoparticles from honey and their use in real-time photoacoustic imaging. Nano Research. 6(5): 312–325. doi:10.1007/s12274-013-0308-8.
  • Yang, X., Zhuo, Y., Zhu, S., Luo, Y., Feng, Y., Dou, Y. (2014). Novel and green synthesis of high-fluorescent carbon dots originated from honey for sensing and imaging. Biosensors and Bioelectronics. 60: 292–298.
  • Yıbar, A., Soyutemiz, E. (2013). Gıda değeri olan hayvanlarda antibiyotik kullanımı ve muhtemel kalıntı riski. Atatürk Üniversitesi Vet. Bil. Derg. 8(1): 97-104.
  • Yu, W.W., Chang, E., Drezek, R., Colvin, V.L. (2006). Water-soluble quantum dots for biomedical applications. Biochemical and Biophysical Research Communications. 348: 781–786
There are 29 citations in total.

Details

Journal Section Research Articles
Authors

SALİHA Dinç

Publication Date November 30, 2017
Acceptance Date September 30, 2017
Published in Issue Year 2017 Volume: 17 Issue: 2

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Vancouver Dinç S. KESTANE BALINDAN SENTEZLENEN KARBON NOKTALARIN TETRASİKLİN ANALİZİNDE KULLANILABİLİRLİĞİNİN ARAŞTIRILMASI. U. Arı. D.-U. Bee J. 2017;17(2):49-58.
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