Klinik Araştırma
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D Vitamini Reseptörü Bsm1 Varyantı, Bruksizm Olan veya Olmayan Temporomandibular Bozuklukla İlişkili Değildir

Yıl 2024, Cilt: 13 Sayı: 1, 100 - 106, 26.01.2024
https://doi.org/10.54617/adoklinikbilimler.1318039

Öz

Amaç:Temporomandibular eklemi ve ilgili yapıları etkileyen bir dizi durum olan temporomandibular eklem bozukluğu (TMD), sıklıkla bruksizm ile bağlantılıdır. D vitamini reseptörü (VDR) kalsiyum emilimini, kemiğin yeniden şekillenmesini ve mineralizasyon hızını etkiler. Bu çalışmanın amacı, VDR Bsm1 (rs1544410) varyantının TMD'de bruksizme duyarlılıktaki rolünü değerlendirmektir.
Gereç ve Yöntemler: Çalışmaya toplam 321 kişi [221 TMB hastası (135 bruksizmli ve 86 bruksizmsiz) ve 100 sağlıklı kontrol] dahil edildi. VDR Bsm1 varyantı, PCR-RFLP yöntemi kullanılarak genotiplendi.
Bulgular: Tüm TMD hasta grubu ile kontrol grubu arasında VDR Bsm1 genotipi ve alel dağılımı açısından anlamlı fark bulunmadı (p>0,05). Gruplarda VDR varyantı için HWE'den sapma olmadı.Bruksizmli hastalarda ağrı özellikleri ile VDR Bsml genotip dağılımı arasında ilişki yoktu.
Sonuç: Sonuçlarımız, VDR Bsm1 varyantının TMD'de bruksizm gelişimi için bir risk faktörü olmadığı sonucunu desteklemektedir. VDR Bsml varyantının TMD'de bruksizm riski üzerindeki etkisi, daha büyük popülasyonları ve diğer etnik kökenleri içeren çalışmalarda araştırılmalıdır.

Destekleyen Kurum

YOK

Proje Numarası

YOK

Kaynakça

  • Referans1. Lobbezoo F, Ahlberg J, Glaros AG, Kato T, Koyano K, Lavigne GJ, de Leeuw R, Manfredini D, Svensson P, Winocur E. Bruxism defined and graded: an international consensus. J Oral Rehabil 2013; 40: 2-4.
  • Referans2. Bayar GR, Tutuncu R, Acikel C. Psychopathological profile of patients with different forms of bruxism. Clin Oral Investig 2012;16: 305-11.
  • Referans3. Manfredini D, Lobbezoo F. Relationship between bruxism and temporomandibular disorders: a systematic review of literature from 1998 to 2008. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;109: e26-50.
  • Referans4. Dworkin SF, Turner JA, Mancl L, Wilson L, Massoth D, Huggins KH, LeResche L, Truelove E. A randomized clinical trial of a tailored comprehensive care treatment program for temporomandibular disorders. J Orofac Pain 2002;16: 259-76.
  • Referans5. Balel Y, Tümer MK. A Bibliometric Analysis of International Publication Trends in Total Temporomandibular Joint Replacement Research (1986-2020). J Oral Maxillofac Surg 2021; 79: 1458.e1- 1458.e12.
  • Referans6. Schmitter M, Rammelsberg P, Hassel A. The prevalence of signs and symptoms of temporomandibular disorders in very old subjects. J Oral Rehabil. 2005; 32:467-73.
  • Referans7. Carlberg C, Molnár F. Detailed molecular understanding of agonistic and antagonistic vitamin D receptor ligands. Curr Top Med Chem 2006; 6: 1243-53.
  • Referans8. Usategui-Martín R, de Luis Román DA, Fernández Gómez JM, VRuiz-Mambrilla M, Pérez Castrillón JL, Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis. Nutrients. 2022;14:360.
  • Referans9. Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP. Genetics and biology of vitamin D receptor polymorphisms. Gene 2004; 338:143-56.
  • Referans10. Uitterlinden AG, Fang Y, van Meurs JB, van Leeuwen H, Pols HA. Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states. J Steroid Biochem Mol Biol 2004;89- 90:187-93.
  • Referans11. Valdivielso JM, Fernandez E. Vitamin D receptor polymorphisms and diseases. Clin Chim Acta 2006; 371:1-12.
  • Referans12. Yildiz S, Tumer MK, Yigit S, Nursal AF, Rustemoglu A, Balel Y. Relation of vitamin D and BsmI variant with temporomandibular diseases in the Turkish population. Br J Oral Maxillofac Surg 2021;59: 555-60.
  • Referans13. Schiffman E, Ohrbach R, Truelove E, Look J, Anderson G, Goulet JP, et al. International RDC/TMD Consortium Network, International association for Dental Research; Orofacial Pain Special Interest Group, International Association for the Study of Pain. Diagnostic Criteria for Temporomandibular Disorders (DC/ TMD) for Clinical and Research Applications: recommendations of the International RDC/TMD Consortium Network* and Orofacial Pain Special Interest Group†. J Oral Facial Pain Headache. 2014;28: 6-27.
  • Referans14. Hong YJ, Kang ES, Ji MJ, Choi HJ, Oh T, Koong SS, Jeon HJ. Association between Bsm1 Polymorphism in Vitamin D Receptor Gene and Diabetic Retinopathy of Type 2 Diabetes in Korean Population. Endocrinol Metab (Seoul) 2015;30: 469-74.
  • Referans15. Bader G, Lavigne G. Sleep bruxism; an overview of an oromandibular sleep movement disorder. REVIEW ARTICLE. Sleep Med Rev 2000; 4: 27-43.
  • Referans16. Janati AB, Alghasab NS, Alghassab FS. Bruxism associated with anoxic encephalopathy: successful treatment with baclofen. Case Rep Dent 2013; 2013:129234.
  • Referans17. Svensson P, Jadidi F, Arima T, Baad-Hansen L, Sessle BJ. Relationships between craniofacial pain and bruxism. J Oral Rehabil 2008; 35: 524-47.
  • Referans18. Mengel R, Candir M, Shiratori K, Flores-de-Jacoby L. Digital volume tomography in the diagnosis of periodontal defects: an in vitro study on native pig and human mandibles. J Periodontol 2005; 76: 665-73.
  • Referans19. Smith SB, Mir E, Bair E, Slade GD, Dubner R, Fillingim RB, Greenspan JD, Ohrbach R, Knott C, Weir B, Maixner W, Diatchenko L. Genetic variants associated with development of TMD and its intermediate phenotypes: the genetic architecture of TMD in the OPPERA prospective cohort study. J Pain 2013;14: T91-101.e1-3.
  • Referans20. Khanna SS, Parulekar NK, Dhaimade PA. The influence of vitamin D on the temporomandibular joint and the activities of daily living. J. Clin. Diagn. Res 2017; 11:31-34.
  • Referans21. Alkhatatbeh MJ, Hmoud ZL, Abdul-Razzak KK, Alem EM. Self –reported sleep bruxism is associated with vitamin D deficiency and low dietary calcium intake: a case-control study. BMC Oral Health 2021; 21:21.
  • Referans22. Maruotti N, Cantatore FP. Vitamin D and the immune system. J Rheumatol 2010; 37: 491-95.
  • Referans23. Tetlow LC, Smith SJ, Mawer EB, Woolley DE. Vitamin D receptors in the rheumatoid lesion: expression by chondrocytes, macrophages, and synoviocytes. Ann Rheum Dis. 1999; 58:118- 21.
  • Referans24. Cantorna MT, Hayes CE, DeLuca HF. 1,25-Dihydroxycholecalciferol inhibits the progression of arthritis in murine models of human arthritis. J Nutr. 1998 ;128:68-72.
  • Referans25. Laragione T, Shah A, Gulko PS. The vitamin D receptor regulates rheumatoid arthritis synovial fibroblast invasion and morphology. Mol Med 2012;18: 194-200.
  • Referans26. Morrison NA, Qi JC, Tokita A, Kelly PJ, Crofts L, Nguyen TV, Sambrook PN, Eisman JA. Prediction of bone density from vitamin D receptor alleles. Nature. 1994; 367: 284-87.
  • Referans27. Mohammadi Z, Keshtkar A, Fayyazbakhsh F, Ebrahimi M, Amoli MM, Ghorbani M, Khashayar P, Dini M, Ebrahimi-Rad M, Larijani B. Prevalence of osteoporosis and vitamin D receptor gene polymorphisms (FokI) in an Iranian general population based study (IMOS). Med J Islam Repub Iran 2015; 29: 238.
  • Referans28. Yılmaz AD. Vitamin D reseptör geni fokI polimorfizminin temporomandibular eklem dejenerasyonu ile ilişkisi. Mersin Univ Saglık Bilim Derg 2019;12: 72-9.
  • Referans29. Yilmaz AD, Yazicioglu D, Tüzüner Öncül AM, Yilmaz E, Ereş G. Vitamin D receptor gene polymorphisms (Apa1 and Taq1) in temporomandibular joint internal derangement/osteoarthritis in a group of Turkish patients. Mol Biol Rep 2018; 45:1839-48.

The Vitamin D Receptor Bsm1 Variant is not Associated With Temporomandibular Disorder With or Without Bruxism

Yıl 2024, Cilt: 13 Sayı: 1, 100 - 106, 26.01.2024
https://doi.org/10.54617/adoklinikbilimler.1318039

Öz

Background: Temporomandibular joint disorder (TMD), a set of conditions that affect the temporomandibular joint and related structures, is frequently linked to bruxism. The vitamin D receptor (VDR) affects calcium absorption, bone remodeling, and mineralization rate. The goal of this study was to evaluate the role of the VDR Bsm1 (rs1544410) variant in the susceptibility to bruxism in TMD.
Method: A total of 321 people [221 TMD patients (135 with bruxism and 86 without bruxism) and 100 healthy controls] were included in the study. The VDR Bsm variant was genotyped using the PCR-RFLP method.
Results: We found no significant difference between the all-TMD patient group and the control group regarding the VDR Bsm1 genotype and allele distribution (p>0.05). There was no deviation from HWE for the VDR variant in groups. There was no relationship between pain characteristics and VDR Bsml genotype distribution in patients with bruxism.
Conclusions: Our results support the conclusion that the VDR Bsm1 variant is not a risk factor for the development of bruxism in TMD. The effect of the VDR Bsml variant on the risk of bruxism in TMD should be investigated in studies involving larger populations and other ethnicities.

Proje Numarası

YOK

Kaynakça

  • Referans1. Lobbezoo F, Ahlberg J, Glaros AG, Kato T, Koyano K, Lavigne GJ, de Leeuw R, Manfredini D, Svensson P, Winocur E. Bruxism defined and graded: an international consensus. J Oral Rehabil 2013; 40: 2-4.
  • Referans2. Bayar GR, Tutuncu R, Acikel C. Psychopathological profile of patients with different forms of bruxism. Clin Oral Investig 2012;16: 305-11.
  • Referans3. Manfredini D, Lobbezoo F. Relationship between bruxism and temporomandibular disorders: a systematic review of literature from 1998 to 2008. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;109: e26-50.
  • Referans4. Dworkin SF, Turner JA, Mancl L, Wilson L, Massoth D, Huggins KH, LeResche L, Truelove E. A randomized clinical trial of a tailored comprehensive care treatment program for temporomandibular disorders. J Orofac Pain 2002;16: 259-76.
  • Referans5. Balel Y, Tümer MK. A Bibliometric Analysis of International Publication Trends in Total Temporomandibular Joint Replacement Research (1986-2020). J Oral Maxillofac Surg 2021; 79: 1458.e1- 1458.e12.
  • Referans6. Schmitter M, Rammelsberg P, Hassel A. The prevalence of signs and symptoms of temporomandibular disorders in very old subjects. J Oral Rehabil. 2005; 32:467-73.
  • Referans7. Carlberg C, Molnár F. Detailed molecular understanding of agonistic and antagonistic vitamin D receptor ligands. Curr Top Med Chem 2006; 6: 1243-53.
  • Referans8. Usategui-Martín R, de Luis Román DA, Fernández Gómez JM, VRuiz-Mambrilla M, Pérez Castrillón JL, Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis. Nutrients. 2022;14:360.
  • Referans9. Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP. Genetics and biology of vitamin D receptor polymorphisms. Gene 2004; 338:143-56.
  • Referans10. Uitterlinden AG, Fang Y, van Meurs JB, van Leeuwen H, Pols HA. Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states. J Steroid Biochem Mol Biol 2004;89- 90:187-93.
  • Referans11. Valdivielso JM, Fernandez E. Vitamin D receptor polymorphisms and diseases. Clin Chim Acta 2006; 371:1-12.
  • Referans12. Yildiz S, Tumer MK, Yigit S, Nursal AF, Rustemoglu A, Balel Y. Relation of vitamin D and BsmI variant with temporomandibular diseases in the Turkish population. Br J Oral Maxillofac Surg 2021;59: 555-60.
  • Referans13. Schiffman E, Ohrbach R, Truelove E, Look J, Anderson G, Goulet JP, et al. International RDC/TMD Consortium Network, International association for Dental Research; Orofacial Pain Special Interest Group, International Association for the Study of Pain. Diagnostic Criteria for Temporomandibular Disorders (DC/ TMD) for Clinical and Research Applications: recommendations of the International RDC/TMD Consortium Network* and Orofacial Pain Special Interest Group†. J Oral Facial Pain Headache. 2014;28: 6-27.
  • Referans14. Hong YJ, Kang ES, Ji MJ, Choi HJ, Oh T, Koong SS, Jeon HJ. Association between Bsm1 Polymorphism in Vitamin D Receptor Gene and Diabetic Retinopathy of Type 2 Diabetes in Korean Population. Endocrinol Metab (Seoul) 2015;30: 469-74.
  • Referans15. Bader G, Lavigne G. Sleep bruxism; an overview of an oromandibular sleep movement disorder. REVIEW ARTICLE. Sleep Med Rev 2000; 4: 27-43.
  • Referans16. Janati AB, Alghasab NS, Alghassab FS. Bruxism associated with anoxic encephalopathy: successful treatment with baclofen. Case Rep Dent 2013; 2013:129234.
  • Referans17. Svensson P, Jadidi F, Arima T, Baad-Hansen L, Sessle BJ. Relationships between craniofacial pain and bruxism. J Oral Rehabil 2008; 35: 524-47.
  • Referans18. Mengel R, Candir M, Shiratori K, Flores-de-Jacoby L. Digital volume tomography in the diagnosis of periodontal defects: an in vitro study on native pig and human mandibles. J Periodontol 2005; 76: 665-73.
  • Referans19. Smith SB, Mir E, Bair E, Slade GD, Dubner R, Fillingim RB, Greenspan JD, Ohrbach R, Knott C, Weir B, Maixner W, Diatchenko L. Genetic variants associated with development of TMD and its intermediate phenotypes: the genetic architecture of TMD in the OPPERA prospective cohort study. J Pain 2013;14: T91-101.e1-3.
  • Referans20. Khanna SS, Parulekar NK, Dhaimade PA. The influence of vitamin D on the temporomandibular joint and the activities of daily living. J. Clin. Diagn. Res 2017; 11:31-34.
  • Referans21. Alkhatatbeh MJ, Hmoud ZL, Abdul-Razzak KK, Alem EM. Self –reported sleep bruxism is associated with vitamin D deficiency and low dietary calcium intake: a case-control study. BMC Oral Health 2021; 21:21.
  • Referans22. Maruotti N, Cantatore FP. Vitamin D and the immune system. J Rheumatol 2010; 37: 491-95.
  • Referans23. Tetlow LC, Smith SJ, Mawer EB, Woolley DE. Vitamin D receptors in the rheumatoid lesion: expression by chondrocytes, macrophages, and synoviocytes. Ann Rheum Dis. 1999; 58:118- 21.
  • Referans24. Cantorna MT, Hayes CE, DeLuca HF. 1,25-Dihydroxycholecalciferol inhibits the progression of arthritis in murine models of human arthritis. J Nutr. 1998 ;128:68-72.
  • Referans25. Laragione T, Shah A, Gulko PS. The vitamin D receptor regulates rheumatoid arthritis synovial fibroblast invasion and morphology. Mol Med 2012;18: 194-200.
  • Referans26. Morrison NA, Qi JC, Tokita A, Kelly PJ, Crofts L, Nguyen TV, Sambrook PN, Eisman JA. Prediction of bone density from vitamin D receptor alleles. Nature. 1994; 367: 284-87.
  • Referans27. Mohammadi Z, Keshtkar A, Fayyazbakhsh F, Ebrahimi M, Amoli MM, Ghorbani M, Khashayar P, Dini M, Ebrahimi-Rad M, Larijani B. Prevalence of osteoporosis and vitamin D receptor gene polymorphisms (FokI) in an Iranian general population based study (IMOS). Med J Islam Repub Iran 2015; 29: 238.
  • Referans28. Yılmaz AD. Vitamin D reseptör geni fokI polimorfizminin temporomandibular eklem dejenerasyonu ile ilişkisi. Mersin Univ Saglık Bilim Derg 2019;12: 72-9.
  • Referans29. Yilmaz AD, Yazicioglu D, Tüzüner Öncül AM, Yilmaz E, Ereş G. Vitamin D receptor gene polymorphisms (Apa1 and Taq1) in temporomandibular joint internal derangement/osteoarthritis in a group of Turkish patients. Mol Biol Rep 2018; 45:1839-48.
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Ağız ve Çene Cerrahisi
Bölüm Araştırma Makalesi
Yazarlar

Serkan Yıldız 0000-0002-5588-9367

Serbülent Yiğit 0000-0002-1019-3964

Ayşe Feyda Nursal 0000-0001-7639-1122

Nevin Karakuş 0000-0002-1916-7471

Mehmet Kemal Tümer 0000-0002-6250-0954

Proje Numarası YOK
Yayımlanma Tarihi 26 Ocak 2024
Gönderilme Tarihi 21 Haziran 2023
Yayımlandığı Sayı Yıl 2024 Cilt: 13 Sayı: 1

Kaynak Göster

Vancouver Yıldız S, Yiğit S, Nursal AF, Karakuş N, Tümer MK. The Vitamin D Receptor Bsm1 Variant is not Associated With Temporomandibular Disorder With or Without Bruxism. ADO Klinik Bilimler Dergisi. 2024;13(1):100-6.