Araştırma Makalesi
TÜRKİYE’NİN DOĞU BÖLGESİNDE 25-HİDROKSİ VİTAMİN SEVİYESİ İLE DİSLİPİDEMİ VE İNSÜLİN REZİSTASINI ARASINDAKİ İLİŞKİ
Öz
Amaç:
D vitamini eksikliği ve yetersizliğinin birçok kronik hastalık ile ilişkili
olduğu kabul edilmektedir. D vitamini, dislipidemi ve insülin
direnci arasındaki ilişki, ilgili hastalıkların erken teşhisi ve tedavisini
sağlayabileceğinden, bu çalışmada D vitamini düzeyleri ile dislipidemi ve
insülin direnci arasındaki ilişkiyi araştırmayı amaçladık.
Gereç
ve yöntemler: Çalışma 249 sağlıklı kişi ile
gerçekleştirilmiştir. Vitamin D dahil olmak üzere laboratuvar testleri yapıldı.
İnsülin direnci, homeostaz model değerlendirme- insülin direnci indeksi ile
hesaplandı. Ayrıca çeşitli vitamin D düzeyleri ile yaş, cinsiyet, glikoz ve
lipit parametreleri ile insülin direnci arasındaki ilişkiyi araştırdık.
Bulgular:
Katılımcıların D vitamini düzeyi erkeklerde kadınlara göre daha yüksekti. Vitamin D
seviyeleri yaş arttıkça azaldı. Katılımcıların% 3.6'sında normal D vitamini
düzeyleri,% 14.5'inde yetersizlik, % 45.0'ında eksiklik, % 36.9'unda ciddi
eksiklik saptandı. İnsülin direnci,
ciddi yetersizliği olanların % 57.6'sında, yetersizliği olanların% 22.3'ünde ve
eksikliği olanların% 8.3'ünde saptandı. Normal D vitamini seviyeleri olanların
hiçbiri insülin direncine sahip değildir. D vitamini grupları arasında lipid
parametresi değerleri açısından anlamlı fark bulunmadı. D vitamini azaldıkça
açlık kan şekeri ve insülin değerleri arttı.
Sonuç:
Sonuç olarak, D vitamini, dislipidemi ve insülin direnci
birbirinden bağımsız olarak kabul edilemez. D vitamini taraması ile eksik
bulunanlar için erken müdahaleler metabolik
sendrom, dislipidemi, diyabet ve obezite gibi diğer hastalıkları önleyebilir.
Anahtar Kelimeler
Kaynakça
- 1.Holick MF. Vitamin D: a D-lightful health perspective. Nutr Rev. 2008;66: 182-194.2.Lind L, Pollare T, Hvarfner A, Lithell H, Sorensen OH, Ljunghall S. Longterm treatment with active vitamin D (alphacalcidol) in middle-aged men with impaired glucose tolerance. Effects on insulin secretion and sensitivity, glucosetolerance and blood pressure. Diabetes Res. 1989;11:141-147.3.Bischoff-Ferrari H, Giovannucci E, Willett S. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84: 18–28.4.Wacker M, Holick MF. Vitamin D-Effects on Skeletal and Extraskeletal Health and the Need for Supplementation. Nutrients 2013;5: 111-148.5.Uçar F, Taşlıpınar MY, Soydaş AÖ, Özcan N. 25-OH vitamin D levels in patients who addmitted to Ankara Etlik Specialized Training Research. Eur J Basic Med Sci. 2012;2: 12-15.6.Bloomgarden ZT. Insulin resistance concepts. Diabetes Care. 2007;30:1320-1326.7.Onat A, Ayhan E, Hergenç G, Can G, Barlan MM. Smoking inhibits visceral fat accumulation in Turkish women: relation of visceral fat and body fat mass to atherogenic dyslipidemia, inflammatory markers, insulin resistance, and blood pressure. Metabolism. 2009;58:963-970.8.Cade C, Norman AW. Rapid normalization/ stimulation by 1,25dihydroxyvitamin D3 of insulin secretion and glucose tolerance in the vitamin D– deficient rat. Endocrinology. 1987;120:1490 –1497.9.Boucher, BJ, Mannan N, Noonan K, Hales CN, Evans SJ. Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians. Diabetologia. 1995; 38:1239-124510.Hollick MF, Krane SM. Introduction to Bone and Mineral Metabolism, in Harrison’s Principles of Internal Medicine. 15th ed, McGraw Hill Companies; 2001: p.2198–2201.11.Keskin M, Kurdoğlu S. Homeostasis Model Assessment Is More Reliable Than the Fasting Glucose/Insulin Ratio and Quantitative Insulin Sensitivity Check Index for Assessing Insulin Resistance Among Obese Children and Adolescents. Pediatrıcs. 2005; 115:500-503.12.Holick MF. Vitamin D Deficiency, Medical Progress. The New England Journal Of Medicine. 2007;357: 266–281.13.Song BM, Kim HC, Choi DP, Oh SM, Suh I. Association between Serum 25-Hydroxyvitamin D Level and Insulin Resistance in a Rural Population. Yonsei Med J. 2014;55:1036-1041.14.Olmez D, Bober E, Buyukgebiz A, Cimrin D. The frequency of vitamin D insufficiency in healthy female adolescents. Acta Paediatr. 2006;95:1266-1269.15.Çizmecioglu FM, Etiler N, Görmüş U, Hamzaoglu H, Hatun Ş. Hypovitaminosis D in Obese and Overweight Schoolchildren. J Clin Res Ped Endo. 2008;1:89–96. 16. Cimbek A, Gürsoy G, Kılıç Z, Acar Y, Demirbaş B. Serum hydroxy vitamin D3 levels in type 2 diabetic patients. Med J Ank Hosp. 2012; 45:14-19.17. Evrim N, Atalay E, Gursoy G, Bayram M, Salman RB. Relationship between levels of vitamin D and metabolic syndrome parameters in patients with metabolic syndrome and healthy individuals. Clinics of Turkey J Endocrinol. 2016:11: 36-45. 18. Koshiyama H, Ikeda H, Honjo S, Nakamura Y, Tanaka K, Tsugawa N et al. Hypovitaminosis D is frequent in Japanese subjects with type 2 diabetes. Diabetes Res Clin Pract. 2007;76:470-471.19. Hyppönen E, Power C. Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity. Diabetes Care. 2006;29:2244-2246.20.Tahrani AA, Ball A, Shepherd L, Rahim A, Jones AF, Bates A. The prevalence of vitamin D abnormalities in South Asians with type 2 diabetes mellitus in the UK. Int J Clin Pract. 2010;64:351-355.21. Farouhi NG, Ye Z, Rickard AP, Khaw KT, Luben R, Langenberg C et al. Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European prospective investigation into cancer (EPIC)-Norfolk color and updated meta-analysis of prospective studies. Diabetologia. 2012;55:2173–2182. 22. Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. 2004;79:820–825. 23. Tsur A, Feldman BS, Feldhammer I, Hoshen MB, Leibowitz G, Balicer RD. Decreased serum concentrations of 25-hydroxycholecalciferol are associated with increased risk of progression to impaired fasting glucose and diabetes. Diabetes Care. 2013;36:1361–1367. 24. Scragg R, Sowers M, Bell C. Serum 25 hydroxy vitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabates Care. 2004; 27:2813-2818. 25. Need AG, O’Loughlin PD, Horowitz M, Nordin BE: Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxy vitamin D in postmenopausal women. Clin Endocrinol (Oxf). 2005;62:738-741.26. Liu E, Meigs JB, Pittas AG, Mc Keown NM, Economos CD, Booth SL, Jacques PF. Plasma 25 hydroxy vitamin D is associated with markers of the insulin resistant phenotype in nondiabetic adults. J Nutr. 2009; 139: 329-334.27. Ford ES, Ajani UA, Mc Guire LC, Luis S. Concentrations of serum Vitamin D and the metabolic syndrome among US adults. Diabetes Care. 2005; 28:1228- 1230.28. Erdönmez D, Hatun S, Çizmecioğlu FM, Keser A. No Relationship Between Vitamin D Status and Insulin Resistance in a Group of High School Students. J Clin Res Pediatr Endocrinol. 2011;3: 198-201.29. Ding L, Wang C, Ma H, Tian Y, Lu Y, Pang S. The Study of Serum Vitamin D and Insulin Resistance in Chinese Populations with Normal Glucose Tolerance. Int J Endocrinol. 2014; 2014:1-4.30. Badawi A, Sayegh S, Sadoun E, Al-Thani M, Arora P, Haddad PS. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2014;7: 297–303.31. Lu L, Yu Z, Pan A, Hu PB, Franco OH, Li H et al. Plasma 25- hyroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals. Diabetes Care. 2009; 32:1278- 83.32. Chaudhuri JR, Mridula KR, Anamika A. Deficiency of 25-hydroxyvitamin D and dyslipidemia in Indian subjects. J Lipids. 2013; 2013:1-7.33. Zhang MC, Li HX, Liu HM. Serum Vitamin D is Low and Inversely Associated with LDL Cholesterol in the Kazak Ethnic Population: A Cross-Sectional Study. Med Sci Monit. 2014;20:1274–1283.34. Toxqui L, Blanco-Rojo R. Changes in blood pressure and lipid levels in young women consuming a vitamin D-fortified skimmed milk: a randomised controlled trial. Nutrients. 2013;5: 4966–77.35. Saedisomeolia A, Taheri E. Association between serum level of vitamin D and lipid profiles in type 2 diabetic patients in Iran. J Diabetes Metab Disorder. 2014;13:7-11.36. Sollid ST, Hutchinson MYS, Fuskevåg OM, Figenschau Y, Joakimsen RM, Schirmer H et al. No effect of high-dose vitamin d supplementation on glycemic status or cardiovascular risk factors in subjects with prediabetes. Diabetes Care. 2014;37:2123–2131.
Yıl 2018,
Cilt: 51 Sayı: 2, 90 - 97, 29.08.2018
Öz
Kaynakça
- 1.Holick MF. Vitamin D: a D-lightful health perspective. Nutr Rev. 2008;66: 182-194.2.Lind L, Pollare T, Hvarfner A, Lithell H, Sorensen OH, Ljunghall S. Longterm treatment with active vitamin D (alphacalcidol) in middle-aged men with impaired glucose tolerance. Effects on insulin secretion and sensitivity, glucosetolerance and blood pressure. Diabetes Res. 1989;11:141-147.3.Bischoff-Ferrari H, Giovannucci E, Willett S. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84: 18–28.4.Wacker M, Holick MF. Vitamin D-Effects on Skeletal and Extraskeletal Health and the Need for Supplementation. Nutrients 2013;5: 111-148.5.Uçar F, Taşlıpınar MY, Soydaş AÖ, Özcan N. 25-OH vitamin D levels in patients who addmitted to Ankara Etlik Specialized Training Research. Eur J Basic Med Sci. 2012;2: 12-15.6.Bloomgarden ZT. Insulin resistance concepts. Diabetes Care. 2007;30:1320-1326.7.Onat A, Ayhan E, Hergenç G, Can G, Barlan MM. Smoking inhibits visceral fat accumulation in Turkish women: relation of visceral fat and body fat mass to atherogenic dyslipidemia, inflammatory markers, insulin resistance, and blood pressure. Metabolism. 2009;58:963-970.8.Cade C, Norman AW. Rapid normalization/ stimulation by 1,25dihydroxyvitamin D3 of insulin secretion and glucose tolerance in the vitamin D– deficient rat. Endocrinology. 1987;120:1490 –1497.9.Boucher, BJ, Mannan N, Noonan K, Hales CN, Evans SJ. Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians. Diabetologia. 1995; 38:1239-124510.Hollick MF, Krane SM. Introduction to Bone and Mineral Metabolism, in Harrison’s Principles of Internal Medicine. 15th ed, McGraw Hill Companies; 2001: p.2198–2201.11.Keskin M, Kurdoğlu S. Homeostasis Model Assessment Is More Reliable Than the Fasting Glucose/Insulin Ratio and Quantitative Insulin Sensitivity Check Index for Assessing Insulin Resistance Among Obese Children and Adolescents. Pediatrıcs. 2005; 115:500-503.12.Holick MF. Vitamin D Deficiency, Medical Progress. The New England Journal Of Medicine. 2007;357: 266–281.13.Song BM, Kim HC, Choi DP, Oh SM, Suh I. Association between Serum 25-Hydroxyvitamin D Level and Insulin Resistance in a Rural Population. Yonsei Med J. 2014;55:1036-1041.14.Olmez D, Bober E, Buyukgebiz A, Cimrin D. The frequency of vitamin D insufficiency in healthy female adolescents. Acta Paediatr. 2006;95:1266-1269.15.Çizmecioglu FM, Etiler N, Görmüş U, Hamzaoglu H, Hatun Ş. Hypovitaminosis D in Obese and Overweight Schoolchildren. J Clin Res Ped Endo. 2008;1:89–96. 16. Cimbek A, Gürsoy G, Kılıç Z, Acar Y, Demirbaş B. Serum hydroxy vitamin D3 levels in type 2 diabetic patients. Med J Ank Hosp. 2012; 45:14-19.17. Evrim N, Atalay E, Gursoy G, Bayram M, Salman RB. Relationship between levels of vitamin D and metabolic syndrome parameters in patients with metabolic syndrome and healthy individuals. Clinics of Turkey J Endocrinol. 2016:11: 36-45. 18. Koshiyama H, Ikeda H, Honjo S, Nakamura Y, Tanaka K, Tsugawa N et al. Hypovitaminosis D is frequent in Japanese subjects with type 2 diabetes. Diabetes Res Clin Pract. 2007;76:470-471.19. Hyppönen E, Power C. Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity. Diabetes Care. 2006;29:2244-2246.20.Tahrani AA, Ball A, Shepherd L, Rahim A, Jones AF, Bates A. The prevalence of vitamin D abnormalities in South Asians with type 2 diabetes mellitus in the UK. Int J Clin Pract. 2010;64:351-355.21. Farouhi NG, Ye Z, Rickard AP, Khaw KT, Luben R, Langenberg C et al. Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European prospective investigation into cancer (EPIC)-Norfolk color and updated meta-analysis of prospective studies. Diabetologia. 2012;55:2173–2182. 22. Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. 2004;79:820–825. 23. Tsur A, Feldman BS, Feldhammer I, Hoshen MB, Leibowitz G, Balicer RD. Decreased serum concentrations of 25-hydroxycholecalciferol are associated with increased risk of progression to impaired fasting glucose and diabetes. Diabetes Care. 2013;36:1361–1367. 24. Scragg R, Sowers M, Bell C. Serum 25 hydroxy vitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabates Care. 2004; 27:2813-2818. 25. Need AG, O’Loughlin PD, Horowitz M, Nordin BE: Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxy vitamin D in postmenopausal women. Clin Endocrinol (Oxf). 2005;62:738-741.26. Liu E, Meigs JB, Pittas AG, Mc Keown NM, Economos CD, Booth SL, Jacques PF. Plasma 25 hydroxy vitamin D is associated with markers of the insulin resistant phenotype in nondiabetic adults. J Nutr. 2009; 139: 329-334.27. Ford ES, Ajani UA, Mc Guire LC, Luis S. Concentrations of serum Vitamin D and the metabolic syndrome among US adults. Diabetes Care. 2005; 28:1228- 1230.28. Erdönmez D, Hatun S, Çizmecioğlu FM, Keser A. No Relationship Between Vitamin D Status and Insulin Resistance in a Group of High School Students. J Clin Res Pediatr Endocrinol. 2011;3: 198-201.29. Ding L, Wang C, Ma H, Tian Y, Lu Y, Pang S. The Study of Serum Vitamin D and Insulin Resistance in Chinese Populations with Normal Glucose Tolerance. Int J Endocrinol. 2014; 2014:1-4.30. Badawi A, Sayegh S, Sadoun E, Al-Thani M, Arora P, Haddad PS. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2014;7: 297–303.31. Lu L, Yu Z, Pan A, Hu PB, Franco OH, Li H et al. Plasma 25- hyroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals. Diabetes Care. 2009; 32:1278- 83.32. Chaudhuri JR, Mridula KR, Anamika A. Deficiency of 25-hydroxyvitamin D and dyslipidemia in Indian subjects. J Lipids. 2013; 2013:1-7.33. Zhang MC, Li HX, Liu HM. Serum Vitamin D is Low and Inversely Associated with LDL Cholesterol in the Kazak Ethnic Population: A Cross-Sectional Study. Med Sci Monit. 2014;20:1274–1283.34. Toxqui L, Blanco-Rojo R. Changes in blood pressure and lipid levels in young women consuming a vitamin D-fortified skimmed milk: a randomised controlled trial. Nutrients. 2013;5: 4966–77.35. Saedisomeolia A, Taheri E. Association between serum level of vitamin D and lipid profiles in type 2 diabetic patients in Iran. J Diabetes Metab Disorder. 2014;13:7-11.36. Sollid ST, Hutchinson MYS, Fuskevåg OM, Figenschau Y, Joakimsen RM, Schirmer H et al. No effect of high-dose vitamin d supplementation on glycemic status or cardiovascular risk factors in subjects with prediabetes. Diabetes Care. 2014;37:2123–2131.
Toplam 1 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 29 Ağustos 2018 |
| Gönderilme Tarihi | 12 Ekim 2018 |
| Yayımlandığı Sayı | Yıl 2018 Cilt: 51 Sayı: 2 |