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İdiyopatik Santral Erken Ergenlik Tanılı Bir Grup Hastanın Başvuru ve Büyüme Özellikleri

Yıl 2021, Cilt: 26 Sayı: 3, 277 - 281, 27.09.2021
https://doi.org/10.21673/anadoluklin.815696

Öz

Amaç: Bu çalışmada idiyopatik santral erken ergenlik (SEE) tanılı hastalarda etiyoloji, prognoz, klinik özellikler ve tedavi yanıtı üzerine bir değerlendirme amaçlanmıştır.
Yöntem: Çocuk endokrinoloji polikliniğimizde Haziran 2001—Eylül 2015 döneminde idiyopatik SEE tanısı konmuş olan toplam 175 hastanın tıbbi kayıtları geriye dönük olarak incelenmiştir.
Bulgular: Hastaların büyük kısmı kız ve 6 yaşından büyük idi. Gonadotropin salgılatıcı hormon analogları ile tedavinin kilo aldırmadığı, erken başvuru ve erken tedavi ile öngörülen boyda artış sağlandığı saptandı.
Sonuç: İdiyopatik SEE’li hastalarda erken tanı ve tedavi büyüme potansiyelinin korunmasında önemli bir rol oynamaktadır.

Kaynakça

  • Terasawa E, Fernandez DL. Neurobiological mechanisms of the onset of the puberty in primates. Endocr Rev. 2001;22:111–51.
  • Wheeler MD. Physical changes of puberty. Endocrinol Metab Clin North Am. 1991;20:1–14.
  • Lee PA, Houk CP. Puberty and its disorders. In: Lifshitz F (ed.), Pediatric Endocrinology, 5. ed. Londra: Informa Healthcare; 2007:272–303.
  • Ebling FJ. The neuroendocrine timing of puberty. Reproduction. 2005;129:675–83.
  • Partsch CJ, Heger S, Sippel WG. Management and outcome central precocious puberty. Clin Endocrinol. 2002;56:129–48.
  • Comite F, Cassoria F, Barnes KM, Hench KD, Dwyer A, Skerda MC, ve ark. Luteinizing hormone releasing hormone analogue therapy for central precocious puberty: long term effect on somatic growth, bone maturation and predicted height. JAMA. 1986;255:2613–6.
  • Oerter KE, Manasco P, Barnes KM, Jones J, Hill S, Cutler GB Jr. Adult height in precocious puberty after long term treatment with doslorelin. J Clin Endocrinol Metab. 1991;73:1235–40.
  • Mul D, Hughes IA. The use of GnRH agonists in precocious puberty. Eur J Endocrinol. 2008;159(ek 1):S3–8.
  • Anasti JN, Flack MR, Froclich J. A potential novel mechanism of precocious puberty in juvenile hypothyroidism. J Clin Endocrinol Metab. 1995;80:276–9.
  • Tanner JM, Whitehouse RH, Marubini E, Resele LF. The adolescent growth spurt of boys and girls of the Harpenden growth study. Ann Hum Biol. 1976;3:109–26.
  • Alikaşifoğlu A, Vuralli D, Gonc EN. Changing etiological trends in male precocious puberty: evalution of 100 cases wih central precocious puberty over the last decade. Horm Res Paediatr. 2015;83:340–4.
  • Gaibicani E, Allali S, Durand A, Sommet J, Couto-Silva AC, Brauner R. Presentation of 493 consecutive girls with idiopathic central precocious puberty: a single center study. PloS One. 2013;8(7):e70931.
  • Ibanez L, de Zegher F. Puberty after prenatal growth restraint. Horm Res. 2006;65(ek 3):112–5.
  • Trivin C, Couta-Silva AC, Sainte-Rose C, Chemaitilly W. Presentation and evolution of organic central precocious puberty according to the type of CNS lesion. Clin Endocrinol. 2001;54:289–94.
  • Wolters B, Lass N, Reinehr T. Treatment with gonadotropin-releasing hormone analogues: different impact on body weight in normal-weight and overweight children. Horm Res Paediatr. 2012;78:304–11.
  • van der Sluis IM, Boot AM, Krenning EP, Drop SLS, Keizer-Schrama SMPFM. Longitudinal follow-up of bone density and body composition in children with precocious or early puberty before, during and after cessation of GnRH agonist therapy. J Clin End Met. 2002;87:506–12.
  • Pasquino AM, Pucarelli I, Passeri F, Segni M, Mancini MA, Municchi G. Progression of premature thelarche to central precocious puberty. J Pediatr. 1995;126:11–4.
  • Carel JC, Lahlou N, Roger M, Chaussain JL. Precocious puberty and statural growth. Human Repr Update. 2004;10(2):135–47.

The Admission and Growth Characteristics of a Group of Patients Diagnosed with Idiopathic Central Precocious Puberty

Yıl 2021, Cilt: 26 Sayı: 3, 277 - 281, 27.09.2021
https://doi.org/10.21673/anadoluklin.815696

Öz

Aim: In this study, we aimed to evaluate the etiology, prognosis, clinical characteristics, and treatment response in patients diagnosed with idiopathic central precocious puberty (CPP).
Methods: We retrospectively reviewed the medical records of a total of 175 patients who were diagnosed with idiopathic CPP at our pediatric endocrinology outpatient clinic between June 2001 and September 2015.
Results: Most of the patients were girls and older than 6 years of age. We found that treatment with gonadotropin-releasing hormone analogues did not cause weight gain, and that younger age at admission and early treatment resulted in an increase in predicted height.
Conclusion: Early diagnosis and treatment play an important role in the preservation of growth potential in patients with idiopathic CPP.

Kaynakça

  • Terasawa E, Fernandez DL. Neurobiological mechanisms of the onset of the puberty in primates. Endocr Rev. 2001;22:111–51.
  • Wheeler MD. Physical changes of puberty. Endocrinol Metab Clin North Am. 1991;20:1–14.
  • Lee PA, Houk CP. Puberty and its disorders. In: Lifshitz F (ed.), Pediatric Endocrinology, 5. ed. Londra: Informa Healthcare; 2007:272–303.
  • Ebling FJ. The neuroendocrine timing of puberty. Reproduction. 2005;129:675–83.
  • Partsch CJ, Heger S, Sippel WG. Management and outcome central precocious puberty. Clin Endocrinol. 2002;56:129–48.
  • Comite F, Cassoria F, Barnes KM, Hench KD, Dwyer A, Skerda MC, ve ark. Luteinizing hormone releasing hormone analogue therapy for central precocious puberty: long term effect on somatic growth, bone maturation and predicted height. JAMA. 1986;255:2613–6.
  • Oerter KE, Manasco P, Barnes KM, Jones J, Hill S, Cutler GB Jr. Adult height in precocious puberty after long term treatment with doslorelin. J Clin Endocrinol Metab. 1991;73:1235–40.
  • Mul D, Hughes IA. The use of GnRH agonists in precocious puberty. Eur J Endocrinol. 2008;159(ek 1):S3–8.
  • Anasti JN, Flack MR, Froclich J. A potential novel mechanism of precocious puberty in juvenile hypothyroidism. J Clin Endocrinol Metab. 1995;80:276–9.
  • Tanner JM, Whitehouse RH, Marubini E, Resele LF. The adolescent growth spurt of boys and girls of the Harpenden growth study. Ann Hum Biol. 1976;3:109–26.
  • Alikaşifoğlu A, Vuralli D, Gonc EN. Changing etiological trends in male precocious puberty: evalution of 100 cases wih central precocious puberty over the last decade. Horm Res Paediatr. 2015;83:340–4.
  • Gaibicani E, Allali S, Durand A, Sommet J, Couto-Silva AC, Brauner R. Presentation of 493 consecutive girls with idiopathic central precocious puberty: a single center study. PloS One. 2013;8(7):e70931.
  • Ibanez L, de Zegher F. Puberty after prenatal growth restraint. Horm Res. 2006;65(ek 3):112–5.
  • Trivin C, Couta-Silva AC, Sainte-Rose C, Chemaitilly W. Presentation and evolution of organic central precocious puberty according to the type of CNS lesion. Clin Endocrinol. 2001;54:289–94.
  • Wolters B, Lass N, Reinehr T. Treatment with gonadotropin-releasing hormone analogues: different impact on body weight in normal-weight and overweight children. Horm Res Paediatr. 2012;78:304–11.
  • van der Sluis IM, Boot AM, Krenning EP, Drop SLS, Keizer-Schrama SMPFM. Longitudinal follow-up of bone density and body composition in children with precocious or early puberty before, during and after cessation of GnRH agonist therapy. J Clin End Met. 2002;87:506–12.
  • Pasquino AM, Pucarelli I, Passeri F, Segni M, Mancini MA, Municchi G. Progression of premature thelarche to central precocious puberty. J Pediatr. 1995;126:11–4.
  • Carel JC, Lahlou N, Roger M, Chaussain JL. Precocious puberty and statural growth. Human Repr Update. 2004;10(2):135–47.
Toplam 18 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm ORJİNAL MAKALE
Yazarlar

Şeyma Sönmez Şahin 0000-0002-2648-3683

Ayla Güven 0000-0002-2026-1326

Yayımlanma Tarihi 27 Eylül 2021
Kabul Tarihi 7 Haziran 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 26 Sayı: 3

Kaynak Göster

Vancouver Şahin ŞS, Güven A. İdiyopatik Santral Erken Ergenlik Tanılı Bir Grup Hastanın Başvuru ve Büyüme Özellikleri. Anadolu Klin. 2021;26(3):277-81.

13151 This Journal licensed under a CC BY-NC (Creative Commons Attribution-NonCommercial 4.0) International License.