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A Multiple Drug-Resistant Streptococcus pneumoniae Caused Acute Otitis Media

Yıl 2020, Cilt: 3 Sayı: 1, 35 - 39, 30.01.2020

Öz

Acute otitis media (AOM), known to be a common pediatric disease is a suppurative infection of the middle ear and air spaces. Causative agent of AOM is often Streptococcus pneumoniae in all the world's children. In the last decades there has been a striking increase in the incidence of penicillin-resistant and multiply antibiotic-resistant pneumococci. The high prevalence of multidrug resistant S. pneumoniae is a clinical problem for medical personnel in the selection of empiric antibacterial treatments. Here we notify a case of a 9-month-old boy with bilateral acute otitis media caused by multi-drug resistant S. pneumoniae. A multiple drug-resistant S. pneumoniae strain was isolated in otorrhea sample obtained from bilateral middle ear of the child with complaints of persistent otitis media. Antibiotic sensibilities were analyzed with disc diffusion and E-test method. The detection of pneumococcal serotype was determined by capsular swelling reaction and sequence type was conducted by multilocus sequence typing (MLST). The serotype was determined as 19A and the sequence type was found ST199. These case report were evaluated in order to draw attention to the increase of pneumococcal AOM infections with multi-drug resistant in among children.

Kaynakça

  • Adegbola RA, DeAntonio R, Hill PC, Roca A, Usuf E, Hoet B, Greenwood BM. (2014). Carriage of Streptococcus pneumoniae and other respiratory bacterial pathogens in low and lower-middle income countries: a systematic review and meta-analysis. PLoS One, 9 (8): e103293.
  • Aşkar Ş, Deveboynu ŞN. (2018). Investigation of In vitro Antibacterial Activitiy of Curcuma Longa Commercial Extract. Eurasian JHS, 1 (1): 1-6.
  • Cartwright KAV. (2005). Bacterial meningitis. In; Borriello P, Murray PR, Funke G, (Ed), Topley and Wilson’s Microbiology and Microbial Infections. 10th ed., London: Hodder Arnold, USA. pp. 555-580.
  • Enginyurt O, Cetinkol Y, Korkmaz M, Yıldırım AA, Korkmaz H, Cankaya S. (2016). Nasopharyngeal carriage rates of streptococcus pneumoniae and changes after conjugate pneumococcal vaccine. Biomed Res, 27: 172-176.
  • Enright MC, Spratt BG. (1998). A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease. Microbiology, 144: 3049-3060.
  • EUCAST. The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 9.0, 2019. http:// www.eucast.org. Accessed 6 June 2019.
  • Fair RJ, Tor Y. (2014). Antibiotics and bacterial resistance in the 21st century. Perspect Medicin Chem, 6: 25-64. Hoberman A, Marchant CD, Kaplan SL, Feldman S. (2002). Treatment of acute otitis media consensus recommendations. Clin Pediatr, 41: 373-390.
  • Kilian M. (2012). Streptococcus and enterococcus: pharyngitis; scarlet fever; skin and soft tissue infections; streptococcal toxic shock syndrome; pneumonia; meningitis; urinary tract infections; rheumatic fever; post-streptococcal glomerulonephritis. In; Greenwood D, Slack RCB, Barer MR, Irving WL, (Ed), Medical microbiology: a guide to microbial infections; pathogenesis, immunity, laboratory diagnosis, and control. 18th ed. London: Churchill Livingstone Elsevier, pp. 183-198.
  • Le Saux N, Robinson JL, Canadian Paediatric Society, Infectious Diseases and Immunization Committee. (2016). Management of acute otitis media in children six months of age and older. Paediatr Child Health, 21: 39-50.
  • Nuorti JP, Whitney CG, Centers for Disease Control and Prevention (CDC). (2010). Prevention of pneumococcal disease among infants and children-use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine-recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep, 59: 1-18.
  • Orlando MP, Bonanno MA, Russo FY, Ralli M, Turchetta R, Passali FM, Minni A, Greco A, De Vincentiis M, Tattoli M. (2019). Correlation between otitis media with effusion and cranial deformation in children. Eur Rev Med Pharmacol Sci, 23: 55-59.
  • Parra A, Ponte C, Cenjor C, Martínez-Marín C, Soriano F, The Spanish Pneumococcal Infection Study Network. (2004). Effect of Antibiotic Treatment Delay on Therapeutic Outcome of Experimental Acute Otitis Media Caused by Streptococcus pneumoniae Strains with Different Susceptibilities to Amoxicillin. Antimicrob Agents Chemother, 48: 860-866.
  • Peter G, Klein JO. (2008). Streptococcus pneumoniae: In; Principles and Practice of Pediatric Infectious Diseases. New York: Churchill Livingstone Elsevier, pp. 725-733.
  • Taneja MK, Taneja V. (2014). Drug therapy for otitis media. Indian J Otol, 20: 1-3. Velasquez PA, Parussolo L, Cardoso CL, Tognim MC, Garcia LB. (2009). High prevalence of children colonized with penicillin-resistant Streptococcus pneumoniae in public day-care centers. J Pediatr, 85: 516-522.
  • Vergison A, Dagan R, Arguedas A, Bonhoeffer J, Cohen R, Dhooge I, Hoberman A, Liese J, Marchisio P, Palmu AA, Ray GT, Sanders EA, Simões EA, Uhari M, van Eldere J, Pelton SI. (2010). Otitis media and its consequences: beyond the earache. Lancet Infect Dis, 10: 195-203.
  • Xu Q, Pichichero ME, Casey JR, Zeng M. (2009). Novel Type of Streptococcus pneumoniae Causing Multidrug-Resistant Acute Otitis Media in Children. Emerg Infect Dis, 15: 547- 551.

Çoklu İlaç Dirençli Streptococcus pneumoniae Kaynaklı Akut Otitis Media

Yıl 2020, Cilt: 3 Sayı: 1, 35 - 39, 30.01.2020

Öz

Akut otitis media (AOM) orta kulak ve hava boşluklarının süpüratif enfeksiyonu olup, yaygın bir pediatrik hastalıktır. AOM'nin etkensel ajanı, tüm dünya çocuklarında sıklıkla Streptococcus pneumoniae'dir. Son birkaç on yılda, penisiline dirençli ve çoklu ilaca dirençli pnömokok insidansında çarpıcı bir artış olmuştur. Çoklu ilaca dirençli S. pneumoniae’nin yüksek prevalansı, ampirik antimikrobiyal tedavi seçiminde uygulayıcılar için klinik bir zorluktur. Bu yazıda, çoklu ilaca dirençli S. pneumoniae'nin neden olduğu iki taraflı akut otitis media’sı olan 9 aylık bir erkek olgu sunuldu. Persistan otitis media şikayeti olan çocuğun iki taraflı orta kulağından elde edilen akıntı örneğinde çoklu ilaca dirençli bir S. pneumoniae suşu izole edildi. Antibiyotik duyarlılıkları disk difüzyon ve E-test yöntemiyle analiz edildi. Pnömokokal serotip tespiti kapsüler şişme reaksiyonu ile belirlendi ve sekans tipi multilokus dizilimiyle (MLST) yapıldı. Serotip 19A olarak belirlendi ve dizi tipi ST199 olarak bulundu. Çocuklarda çoklu ilaca dirençli pnömokokal AOM infeksiyonlarının artışına dikkat çekmek amacıyla bu olgu sunumu değerlendirilmiştir.

Kaynakça

  • Adegbola RA, DeAntonio R, Hill PC, Roca A, Usuf E, Hoet B, Greenwood BM. (2014). Carriage of Streptococcus pneumoniae and other respiratory bacterial pathogens in low and lower-middle income countries: a systematic review and meta-analysis. PLoS One, 9 (8): e103293.
  • Aşkar Ş, Deveboynu ŞN. (2018). Investigation of In vitro Antibacterial Activitiy of Curcuma Longa Commercial Extract. Eurasian JHS, 1 (1): 1-6.
  • Cartwright KAV. (2005). Bacterial meningitis. In; Borriello P, Murray PR, Funke G, (Ed), Topley and Wilson’s Microbiology and Microbial Infections. 10th ed., London: Hodder Arnold, USA. pp. 555-580.
  • Enginyurt O, Cetinkol Y, Korkmaz M, Yıldırım AA, Korkmaz H, Cankaya S. (2016). Nasopharyngeal carriage rates of streptococcus pneumoniae and changes after conjugate pneumococcal vaccine. Biomed Res, 27: 172-176.
  • Enright MC, Spratt BG. (1998). A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease. Microbiology, 144: 3049-3060.
  • EUCAST. The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 9.0, 2019. http:// www.eucast.org. Accessed 6 June 2019.
  • Fair RJ, Tor Y. (2014). Antibiotics and bacterial resistance in the 21st century. Perspect Medicin Chem, 6: 25-64. Hoberman A, Marchant CD, Kaplan SL, Feldman S. (2002). Treatment of acute otitis media consensus recommendations. Clin Pediatr, 41: 373-390.
  • Kilian M. (2012). Streptococcus and enterococcus: pharyngitis; scarlet fever; skin and soft tissue infections; streptococcal toxic shock syndrome; pneumonia; meningitis; urinary tract infections; rheumatic fever; post-streptococcal glomerulonephritis. In; Greenwood D, Slack RCB, Barer MR, Irving WL, (Ed), Medical microbiology: a guide to microbial infections; pathogenesis, immunity, laboratory diagnosis, and control. 18th ed. London: Churchill Livingstone Elsevier, pp. 183-198.
  • Le Saux N, Robinson JL, Canadian Paediatric Society, Infectious Diseases and Immunization Committee. (2016). Management of acute otitis media in children six months of age and older. Paediatr Child Health, 21: 39-50.
  • Nuorti JP, Whitney CG, Centers for Disease Control and Prevention (CDC). (2010). Prevention of pneumococcal disease among infants and children-use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine-recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep, 59: 1-18.
  • Orlando MP, Bonanno MA, Russo FY, Ralli M, Turchetta R, Passali FM, Minni A, Greco A, De Vincentiis M, Tattoli M. (2019). Correlation between otitis media with effusion and cranial deformation in children. Eur Rev Med Pharmacol Sci, 23: 55-59.
  • Parra A, Ponte C, Cenjor C, Martínez-Marín C, Soriano F, The Spanish Pneumococcal Infection Study Network. (2004). Effect of Antibiotic Treatment Delay on Therapeutic Outcome of Experimental Acute Otitis Media Caused by Streptococcus pneumoniae Strains with Different Susceptibilities to Amoxicillin. Antimicrob Agents Chemother, 48: 860-866.
  • Peter G, Klein JO. (2008). Streptococcus pneumoniae: In; Principles and Practice of Pediatric Infectious Diseases. New York: Churchill Livingstone Elsevier, pp. 725-733.
  • Taneja MK, Taneja V. (2014). Drug therapy for otitis media. Indian J Otol, 20: 1-3. Velasquez PA, Parussolo L, Cardoso CL, Tognim MC, Garcia LB. (2009). High prevalence of children colonized with penicillin-resistant Streptococcus pneumoniae in public day-care centers. J Pediatr, 85: 516-522.
  • Vergison A, Dagan R, Arguedas A, Bonhoeffer J, Cohen R, Dhooge I, Hoberman A, Liese J, Marchisio P, Palmu AA, Ray GT, Sanders EA, Simões EA, Uhari M, van Eldere J, Pelton SI. (2010). Otitis media and its consequences: beyond the earache. Lancet Infect Dis, 10: 195-203.
  • Xu Q, Pichichero ME, Casey JR, Zeng M. (2009). Novel Type of Streptococcus pneumoniae Causing Multidrug-Resistant Acute Otitis Media in Children. Emerg Infect Dis, 15: 547- 551.
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Araştırma Makaleleri
Yazarlar

Fatma Koksal Cakirlar Bu kişi benim 0000-0002-9744-5748

Serhat Sirekbasan 0000-0001-7967-3539

Ebru Tugrul Saribeyoglu Bu kişi benim 0000-0003-3294-5394

Emine Er Bu kişi benim 0000-0003-4738-9749

Mustafa Samasti Bu kişi benim 0000-0002-3879-7196

Yayımlanma Tarihi 30 Ocak 2020
Gönderilme Tarihi 22 Ekim 2019
Yayımlandığı Sayı Yıl 2020 Cilt: 3 Sayı: 1

Kaynak Göster

APA Koksal Cakirlar, F., Sirekbasan, S., Tugrul Saribeyoglu, E., Er, E., vd. (2020). A Multiple Drug-Resistant Streptococcus pneumoniae Caused Acute Otitis Media. Avrasya Sağlık Bilimleri Dergisi, 3(1), 35-39.
AMA Koksal Cakirlar F, Sirekbasan S, Tugrul Saribeyoglu E, Er E, Samasti M. A Multiple Drug-Resistant Streptococcus pneumoniae Caused Acute Otitis Media. AvrasyaSBD. Ocak 2020;3(1):35-39.
Chicago Koksal Cakirlar, Fatma, Serhat Sirekbasan, Ebru Tugrul Saribeyoglu, Emine Er, ve Mustafa Samasti. “A Multiple Drug-Resistant Streptococcus Pneumoniae Caused Acute Otitis Media”. Avrasya Sağlık Bilimleri Dergisi 3, sy. 1 (Ocak 2020): 35-39.
EndNote Koksal Cakirlar F, Sirekbasan S, Tugrul Saribeyoglu E, Er E, Samasti M (01 Ocak 2020) A Multiple Drug-Resistant Streptococcus pneumoniae Caused Acute Otitis Media. Avrasya Sağlık Bilimleri Dergisi 3 1 35–39.
IEEE F. Koksal Cakirlar, S. Sirekbasan, E. Tugrul Saribeyoglu, E. Er, ve M. Samasti, “A Multiple Drug-Resistant Streptococcus pneumoniae Caused Acute Otitis Media”, AvrasyaSBD, c. 3, sy. 1, ss. 35–39, 2020.
ISNAD Koksal Cakirlar, Fatma vd. “A Multiple Drug-Resistant Streptococcus Pneumoniae Caused Acute Otitis Media”. Avrasya Sağlık Bilimleri Dergisi 3/1 (Ocak 2020), 35-39.
JAMA Koksal Cakirlar F, Sirekbasan S, Tugrul Saribeyoglu E, Er E, Samasti M. A Multiple Drug-Resistant Streptococcus pneumoniae Caused Acute Otitis Media. AvrasyaSBD. 2020;3:35–39.
MLA Koksal Cakirlar, Fatma vd. “A Multiple Drug-Resistant Streptococcus Pneumoniae Caused Acute Otitis Media”. Avrasya Sağlık Bilimleri Dergisi, c. 3, sy. 1, 2020, ss. 35-39.
Vancouver Koksal Cakirlar F, Sirekbasan S, Tugrul Saribeyoglu E, Er E, Samasti M. A Multiple Drug-Resistant Streptococcus pneumoniae Caused Acute Otitis Media. AvrasyaSBD. 2020;3(1):35-9.