Araştırma Makalesi
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Is There Relationship Between Stuttering and Hematological Parameters in Children?

Yıl 2022, Cilt: 19 Sayı: 2, 338 - 342, 28.08.2022
https://doi.org/10.35440/hutfd.1066429

Öz

Background: We aimed to evaluate MPV in children followed-up for stuttering.
Materials and Methods: The study included a total of 155 individuals, comprising 55 in the patient group with a stutter and 100 in the control group. EDTA blood samples drawn at admission of the patient were analyzed in an automated hematology analysis system. MPV, white blood cell, neutrophil, lymphocyte, platelet count, neutrophil- lymphocyte ratio(NLR), platelet- lymphocyte ratio(PLR) and Systemic Immun Inflamation Index(SII) were measured.
Results: The mean age was 8.93±3.87 years (min:4-max:15) in the stuttering group and 8.73±3.21 years (min:5 max: 15) in the control group. MPV, white blood cell, neutrophil, lymphocyte, platelet count, PLR and SII were higher in patient group compared to the controls and the difference was statistically significant (p<0,05).
Conclusion: In this study, MPV was found to increase in stuttering children. Also, we believe that the use of new markers such as MPV in children with stuttering could be a guiding parameter in determination inflammatory status.

Kaynakça

  • A.C. Etchell, B.W. Johnson, P.F. Sowman. Behavioral and multimodal neuroimaging evidence for a deficit in brain timing Networks in stuterring: a hypothesis and theory. Front. Hum. Neurosci., 2014 ;8 : 467.
  • M. Lawrence, D.M. Barclay. Stuttering: a brief review. Am. Fam. Physician. 1998; 57 :2175-2178
  • A.R. Mawson, N.T. Radford, B. Jacob. Toward a theory of stuttering. Eur. Neurol. 2016;76 : 244-251
  • C. Fagnani, S. Fibiger, A. Skytthe, J. Hjelmborg. Heritability and environmental effects for self-reported periods with stuttering: a twin study from Denmark, Logoped. Phoniatr. Vocol. 2011; 36: 114-120.
  • Chang SE, Erickson KI, Ambrose NG, Hasegawa-Johnson MA, Ludlow CL. Brain anatomy differences in childhood stuttering. NeuroImage 2008; 39: 1333-44.
  • Witmer CM. Hematologic manifestations of systemic disease (including iron deficiency, anemia of inflammation and DIC). Pediatr Clin North Am. 2013;60(6):1337-48.
  • Giles C. Platelet count and mean platelet volume. Br J Haematol. 1981;48:31–37.
  • Furuncuoğlu Y, Tulgar S, Dogan AN, Cakar S, Tulgar YK, Cakiroglu B. How obesity affects the neutrophil/lymphocyte and platelet/lymphocyte ratio, systemic immune-inflammatory index and platelet indices: a retrospective study. Eur Rev Med Pharmacol Sci. 2016;20(7):1300-6.
  • Amerikan Psikiyatri Birliği, Ruhsal Bozuklukların Tanısal ve Sayımsal Elkitabı, Beşinci Baskı (DSM-5), Tanı Ölçütleri Başvuru Elkitabı’ndan çeviri. Köroğlu E, Hekimler Yayın Birliği, Ankara, (2014).
  • G.A. Maquire, A.A. Bird Gabapentin for treating acquired neurogenic stuttering Ann. Clin. Psychiatry,2012; 24: 240.
  • Wu JC, Maguire G, Riley G, Lee A, Keator D, Tang C, et al. Increased dopamine activity associated with stuttering, Neuroreport. 1997;8:767-770.
  • Steidl L, Pesak J, Chytilova H. Stuttering and tetanic syndrome. Folia Phoniatr. 1991;43:7-12.
  • C. Büchel, M. Sommer What causes stuttering? PLoS Biol.2004; 2 : 46
  • Budak Y. U, Polat M, Huysal K. The use of platelet indices, plateletcrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: a systematic review. Biochemical Medicine. 2016;26(2):178–193.
  • Koç S. Eyibilen A., Erdoğan A. S. Mean platelet volume as an inflammatory marker in chronic sinusitis. European Journal of General Medicine. 2011;8(4):314–317.
  • The influence of clinical characteristics, laboratory and inflammatory markers on 'high on-treatment platelet reactivity' as measured with different platelet function tests. Elsenberg EH, van Werkum JW, van de Wal RM, Zomer AC, Bouman HJ, Verheugt FW, Berg JM, Hackeng CM Thromb Haemost. 2009 ;102(4):719-27.
  • Greisenegger S, Endler G, Hsieh K, Tentschert S, Mannhalter C, Lalouschek W. Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events? Stroke. 2004;35(7):1688–1691.
  • Kurt M. Onal I. K, Sayilir A. Y, et al. The role of mean platelet volume in the diagnosis of hepatocellular carcinoma in patients with chronic liver disease. Hepato - Gastroenterology. 2012;59(117):1580–1582.
  • Kılınçalp S, Ekiz F, Başar Ö. et al. Mean platelet volume could be possible biomarker in early diagnosis and monitoring of gastric cancer. Platelets. 2013;25(8):592–594.
  • Zhang F. Chen Z, Wang, Hu X, Gao Y, He J. Combination of platelet count and mean platelet volume (COP-MPV) predicts postoperative prognosis in both resectable early and advanced stage esophageal squamous cell cancer patients. Tumor Biology. 2016;37(7):9323–9331.
  • Desai J, Huo Y, Wang Z, Bansal R, Williams SC, Lythgoe D, Zelaya FO, Peterson BS. Reduced perfusion in Broca's area in developmental stuttering. Hum Brain Mapp. 2017 Apr;38(4):1865-1874.
  • Yang R, Chang Q, Meng X, Gao N, Wang W. Prognostic value of systemic immune-inflammation index in cancer: a meta-analysis. J Cancer 2018;9(18):3295–3302.
  • Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP. Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015;14(4):388-405.
  • Yang YL, Wu CH, Hsu PF, Chen SC, Huang SS, Chan WL, Lin SJ, Chou CY, Chen JW, Pan JP, Charng MJ, Chen YH, Wu TC, Lu TM, Huang PH, Cheng HM, Huang CC, Sung SH, Lin YJ, Leu HB. Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease. Eur J Clin Invest. 2020 ;50(5):13230.
  • Soliman WM, Sherif NM, Ghanima IM, El-Badawy MA. Neutrophil to lymphocyte and platelet to lymphocyte ratios in systemic lupus erythematosus: Relation with disease activity and lupus nephritis. Reumatol Clin (Engl Ed). 2020;16(4):255-261.
  • Pourafkari L, Wang CK, Tajlil A, Afshar AH, Schwartz M, Nader ND. platelet-lymphocyte ratio in prediction of outcome of acute heart failure. Biomark Med. 2018;12(1):63-70.
  • Song W, Wang K, Zhong FP, Fan YW, Peng L, Zou SB. Clinicopathological and prognostic significance of platelet-to-lymphocyte ratio in patients with hepatocellular carcinoma. Oncotarget. 2016;7(49):81830-81838.
  • Beal DS, Lerch JP, Cameron B, Henderson R, Gracco VL, De Nil LF The trajectory of gray matter development in Broca's area is abnormal in people who stutter. Front Hum Neurosci 2015; 9:89.
  • Chang SE, Zhu DC, Choo AL, Angstadt M. White matter neuroanatomical differences in young children who stutter. Brain 2015; 138:694–711.
  • Cai S, Tourville JA, Beal DS, Perkell JS, Guenther FH, Ghosh SS. Diffusion imaging of cerebral white matter in persons who stutter: evidence for network-level anomalies. Front Hum Neurosci. 2014; 11;8:54.
  • Reinhart WH. Hemorheology: Blood flow hematology. Schweiz Med Woochenschr 1995;125:387-395.

Çocuklarda Kekemelik ve Hematolojik Parametreler Arasında İlişki Var mı?

Yıl 2022, Cilt: 19 Sayı: 2, 338 - 342, 28.08.2022
https://doi.org/10.35440/hutfd.1066429

Öz

Amaç: Çalışmamızın amacı pediatrik yaş grubunda kekemelik sorunu olanlarda hematolojik parametreler ve özellikle Ortalama Trombosit Hacim(MPV) değerlerini değerlendirmektir.
Materyal- Metod: Çalışmada 55 kekeme hastası ve 100 kişilik kontrol grubu mevcuttur. Hasta kabulünü takiben hastalardan alınan EDTA’lı kan örnekleri otomatik hematoloji analizörü ile analiz edilerek MPV, Beyaz Kan hücreleri, Platelet, Nötrofil, Lenfosit, Nötrofil/Lenfosit Oranı (NLO),Trombosit/Lenfosit Oranı(TLO) ve Sistemik İmmun inflamasyon indeksi(SII) değerleri ölçüldü.
Bulgular: kekeme grubunun ortalama yaşı 8.93±3.87, kontrol grubunun ise 8.73±3.21 idi. kekemelik sorunu olan hastalarda MPV, Beyaz kan hücre sayısı, Trombosit, Nötrofil, Lenfosit, TLO ve SII istatistiksel açıdan anlamlı yüksek idi.
Sonuç: Bu çalışmada kekemelik sorunu olan çocuklarda Hematolojik parametreler ve özellikle MPV değeri yüksek bulundu. Kekeme çocuklarda MPV gibi hematolojik belirteçlerin kullanılması etyolojide suçlanan kronik inflamatuar durumun belirlenmesinde yol gösterici olabileceği düşüncesindeyiz.

Kaynakça

  • A.C. Etchell, B.W. Johnson, P.F. Sowman. Behavioral and multimodal neuroimaging evidence for a deficit in brain timing Networks in stuterring: a hypothesis and theory. Front. Hum. Neurosci., 2014 ;8 : 467.
  • M. Lawrence, D.M. Barclay. Stuttering: a brief review. Am. Fam. Physician. 1998; 57 :2175-2178
  • A.R. Mawson, N.T. Radford, B. Jacob. Toward a theory of stuttering. Eur. Neurol. 2016;76 : 244-251
  • C. Fagnani, S. Fibiger, A. Skytthe, J. Hjelmborg. Heritability and environmental effects for self-reported periods with stuttering: a twin study from Denmark, Logoped. Phoniatr. Vocol. 2011; 36: 114-120.
  • Chang SE, Erickson KI, Ambrose NG, Hasegawa-Johnson MA, Ludlow CL. Brain anatomy differences in childhood stuttering. NeuroImage 2008; 39: 1333-44.
  • Witmer CM. Hematologic manifestations of systemic disease (including iron deficiency, anemia of inflammation and DIC). Pediatr Clin North Am. 2013;60(6):1337-48.
  • Giles C. Platelet count and mean platelet volume. Br J Haematol. 1981;48:31–37.
  • Furuncuoğlu Y, Tulgar S, Dogan AN, Cakar S, Tulgar YK, Cakiroglu B. How obesity affects the neutrophil/lymphocyte and platelet/lymphocyte ratio, systemic immune-inflammatory index and platelet indices: a retrospective study. Eur Rev Med Pharmacol Sci. 2016;20(7):1300-6.
  • Amerikan Psikiyatri Birliği, Ruhsal Bozuklukların Tanısal ve Sayımsal Elkitabı, Beşinci Baskı (DSM-5), Tanı Ölçütleri Başvuru Elkitabı’ndan çeviri. Köroğlu E, Hekimler Yayın Birliği, Ankara, (2014).
  • G.A. Maquire, A.A. Bird Gabapentin for treating acquired neurogenic stuttering Ann. Clin. Psychiatry,2012; 24: 240.
  • Wu JC, Maguire G, Riley G, Lee A, Keator D, Tang C, et al. Increased dopamine activity associated with stuttering, Neuroreport. 1997;8:767-770.
  • Steidl L, Pesak J, Chytilova H. Stuttering and tetanic syndrome. Folia Phoniatr. 1991;43:7-12.
  • C. Büchel, M. Sommer What causes stuttering? PLoS Biol.2004; 2 : 46
  • Budak Y. U, Polat M, Huysal K. The use of platelet indices, plateletcrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: a systematic review. Biochemical Medicine. 2016;26(2):178–193.
  • Koç S. Eyibilen A., Erdoğan A. S. Mean platelet volume as an inflammatory marker in chronic sinusitis. European Journal of General Medicine. 2011;8(4):314–317.
  • The influence of clinical characteristics, laboratory and inflammatory markers on 'high on-treatment platelet reactivity' as measured with different platelet function tests. Elsenberg EH, van Werkum JW, van de Wal RM, Zomer AC, Bouman HJ, Verheugt FW, Berg JM, Hackeng CM Thromb Haemost. 2009 ;102(4):719-27.
  • Greisenegger S, Endler G, Hsieh K, Tentschert S, Mannhalter C, Lalouschek W. Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events? Stroke. 2004;35(7):1688–1691.
  • Kurt M. Onal I. K, Sayilir A. Y, et al. The role of mean platelet volume in the diagnosis of hepatocellular carcinoma in patients with chronic liver disease. Hepato - Gastroenterology. 2012;59(117):1580–1582.
  • Kılınçalp S, Ekiz F, Başar Ö. et al. Mean platelet volume could be possible biomarker in early diagnosis and monitoring of gastric cancer. Platelets. 2013;25(8):592–594.
  • Zhang F. Chen Z, Wang, Hu X, Gao Y, He J. Combination of platelet count and mean platelet volume (COP-MPV) predicts postoperative prognosis in both resectable early and advanced stage esophageal squamous cell cancer patients. Tumor Biology. 2016;37(7):9323–9331.
  • Desai J, Huo Y, Wang Z, Bansal R, Williams SC, Lythgoe D, Zelaya FO, Peterson BS. Reduced perfusion in Broca's area in developmental stuttering. Hum Brain Mapp. 2017 Apr;38(4):1865-1874.
  • Yang R, Chang Q, Meng X, Gao N, Wang W. Prognostic value of systemic immune-inflammation index in cancer: a meta-analysis. J Cancer 2018;9(18):3295–3302.
  • Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP. Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015;14(4):388-405.
  • Yang YL, Wu CH, Hsu PF, Chen SC, Huang SS, Chan WL, Lin SJ, Chou CY, Chen JW, Pan JP, Charng MJ, Chen YH, Wu TC, Lu TM, Huang PH, Cheng HM, Huang CC, Sung SH, Lin YJ, Leu HB. Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease. Eur J Clin Invest. 2020 ;50(5):13230.
  • Soliman WM, Sherif NM, Ghanima IM, El-Badawy MA. Neutrophil to lymphocyte and platelet to lymphocyte ratios in systemic lupus erythematosus: Relation with disease activity and lupus nephritis. Reumatol Clin (Engl Ed). 2020;16(4):255-261.
  • Pourafkari L, Wang CK, Tajlil A, Afshar AH, Schwartz M, Nader ND. platelet-lymphocyte ratio in prediction of outcome of acute heart failure. Biomark Med. 2018;12(1):63-70.
  • Song W, Wang K, Zhong FP, Fan YW, Peng L, Zou SB. Clinicopathological and prognostic significance of platelet-to-lymphocyte ratio in patients with hepatocellular carcinoma. Oncotarget. 2016;7(49):81830-81838.
  • Beal DS, Lerch JP, Cameron B, Henderson R, Gracco VL, De Nil LF The trajectory of gray matter development in Broca's area is abnormal in people who stutter. Front Hum Neurosci 2015; 9:89.
  • Chang SE, Zhu DC, Choo AL, Angstadt M. White matter neuroanatomical differences in young children who stutter. Brain 2015; 138:694–711.
  • Cai S, Tourville JA, Beal DS, Perkell JS, Guenther FH, Ghosh SS. Diffusion imaging of cerebral white matter in persons who stutter: evidence for network-level anomalies. Front Hum Neurosci. 2014; 11;8:54.
  • Reinhart WH. Hemorheology: Blood flow hematology. Schweiz Med Woochenschr 1995;125:387-395.
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Araştırma Makalesi
Yazarlar

Saime Sağıroğlu 0000-0003-2608-7274

Muhammed Gazi Yıldız 0000-0002-1880-0685

Yayımlanma Tarihi 28 Ağustos 2022
Gönderilme Tarihi 1 Şubat 2022
Kabul Tarihi 8 Ağustos 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 19 Sayı: 2

Kaynak Göster

Vancouver Sağıroğlu S, Yıldız MG. Çocuklarda Kekemelik ve Hematolojik Parametreler Arasında İlişki Var mı?. Harran Üniversitesi Tıp Fakültesi Dergisi. 2022;19(2):338-42.

Harran Üniversitesi Tıp Fakültesi Dergisi  / Journal of Harran University Medical Faculty