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An Evaluation of Thrombocyte Functions in Patients with Idiopathic Subjective Tinnitus

Yıl 2022, Cilt: 17 Sayı: 2, 155 - 159, 15.07.2022
https://doi.org/10.17517/ksutfd.1050504

Öz

Objective: The aim of this study was to investigate the thrombocyte agggregation levels which are triggered by adenosine diphosphate (ADP) and collagen in patients with idiopathic subjective tinnitus.
Material and Methods: The study included 33 patients who presented at the clinic with complaints of idiopathic subjective tinnitus that had been ongoing for at least 1 year and a control group of 33 subjects with no complaints of tinnitus. The Tinnitus Handicap Index (THI) was completed by all the patients to
measure tinnitus severity. Thrombocyte count, prothrombin time (PT), and partial thromboplastin time (aPTT) were examined in blood samples taken from the patients. Adenosine diphosphate (ADP) collagenase and epinephrine collagenase were measured in the blood.
Results: According to the THI, 4 (12.1%) patients were grade 1, 8 (24.2%) patients were grade 2, 10 (30.3%) patients were grade 3, 7 (21.2%) were grade 4 and 4 (12.1%) patients were grade 5. Mean aggregation triggered by ADP was determined as 83.85±16.80%in the tinnitus patients and 91.88±20.67% in the
control group, with no statistically significant difference determined (p>0.05). The mean thrombocyte aggregation triggered by collagen was determined as 119.24±24.76% in the tinnitus patients and 130.79±38.73% in the control group, with no statistically significant difference determined (p>0.05).
Conclusion: The thrombocyte functions were evaluated as normal in patients with idiopathic subjective tinnitus. However, as the measured values were lower than those of the control group, there was determined to be a tendency for thrombocyte aggregation.

Kaynakça

  • Nondahl DM, Cruickshanks KJ, Wiley TL, Klein R, Klein BE, Tweed TS. Prevalence and 5-year incidence of tinnitus among older adults: The epidemiology of hearing loss study. J Am Acad Audiol. 2002;13:323-331.
  • Jastreboff PJ, Gray WC, Mattox DE. Tinnitus and hyper acusis. In: Cummings CW, Fredrickson JM, Harker LA, Krause CJ, Richardson MA, Schuller DE, (eds). Otolaryngology Head and Neck Surgery. 3rd ed. Philadelphia: Mosby year Book; 1998.
  • Davis A, El Rafaie A. Epidemiology of tinnitus. In: Tyler RS, ed. Tinnitus handbook. San Diego, CA: Singular, Thomson Learning, 2000:1–23.
  • Baguley D, McFerran D, Hall D. Tinnitus. Lancet. 2013;382:1600–1607.
  • De Ridder D, Verstraeten E, Van der Kelen K, De Mulder G, Sunaert S, Verlooy J et al. Transcranial magnetic stimulation for tinnitus: influence of tinnitus duration on stimulation parameter choice and maximal tinnitus suppression. Otol Neurotol. 2005;26:616–619.
  • Norena A, Micheyl C, Chery-Croze S, Collet L. Psycho acoustic characterization of the tinnitus spectrum: implications for the underlying mechanisms of tinnitus. Audiol Neuro Otol. 2002;7:358–369.
  • Schecklmann M, Vielsmeier V, Steffens T, Landgrebe M, Langguth B, Kleinjung T. Relationship between audiometric slope and tinnitus pitch in tinnitus patients: insights into the mechanisms of tinnitus generation. PLoS One. 2012;7:e34878.
  • Schaette R, McAlpine D. Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model. J Neurosci. 2011;31:13452–13457.
  • Weisz N, Hartmann T, Dohrmann K, Schlee W, Norena A. High- frequency tinnitus without hearing loss does not mean absence of deafferentation. Hear Res. 2006;222:108–114.
  • McKenna L, Hallam RS, Hinchcliffe R. The prevalence of psychological disturbance in neuro-otology outpatients. Clin Otolaryngol Allied Sci. 1991;16:452–456.
  • Saldanha AD, Hilgenberg PB, Pinto LM, Conti PC. Are temporomandibular disorders and tinnitus associated? Cranio. 2012;30:166–171.
  • Born GV. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature. 1962;194:927–929.
  • O’Brien JR. The adhesiveness of native platelets and its prevention. J Clin Pathol. 1961;14:140–149.
  • Favaloro EJ. Clinical application of the PFA-100. Curr Opin Hematol. 2002; 9:407-415.
  • Franchini M. The platelet function analyzer (PFA-100): an update on its clinical use. Clin Lab. 2005;51:367-372.
  • Dikmen ZG, Akbıyık F. Trombosit fonksiyon testleri. Turk J Biochem. 2014;39:549–553.
  • Eggermont J, Roberts L. The neuroscience of tinnitus. Trends Neurosci. 2004;27:676–682.
  • Noreña AJ. An integrative model of tinnitus based on a central gain controlling neura lsensitivity. Neurosci Biobehav Rev. 2011;35:1089–1109.
  • Nondahl DM, Cruickshanks KJ, Huang GH, Klein BE, Klein R, Nieto FJ et al. Tinnitus and its risk factors in the Beaver Dam off spring study. Int J Audiol. 2011;50:313–320.
  • Daemen MA, van’tVeer C, Denecker G, Heemskerk VH, Wolfs TG, Clauss M et al. Inhibition of apoptosis induced by ischemia- reperfusion prevents inflammation. J Clin Invest. 1999;104:541–549.
  • Ozbay I, Kahraman C, Balikci HH, Kucur C, Kahraman NK, Ozkaya DP et al. Neutrophil-to-lymphocyte ratio in patients with severe tinnitus: prospective, controlled clinical study. J Laryngol Otol. 2015;129:544–547.
  • Kemal O, Muderris T, Basar F, Kutlar G, Gul F. Prognostic value of mean platelet volume on tinnitus. J Laryngol Otol. 2015;14:1–4.
  • Del Vecchio A, Motta M, Romagnoli C. Neonatal platelet function. Clin Perinatol. 2015;42:625–638.
  • Cattaneo M, Gachet C. ADP receptors and clinical bleeding disorders. Arterioscler Thromb Vasc Biol. 1999;19:2281-2285.
  • Rao AK. Congenital disorders of platelet function. In: Colman RW, Rao AK, (eds). Platelets in Health and Disease: Hematol/ OncolClin North Am. 1990.
  • Cattaneo M. Hereditary defect of theplatelet ADP receptor(s). Platelets. 1998;8:161–164.
  • Israels SJ, Cheang T, McMillan-Ward EM, Cheang M. Evaluation of primary hemostasis in neonates with a new in vitro platelet function analyzer. J Pediatr. 2001;138:116–119.
  • Eistert B, Kirchmaier C, Risse M, Glanz H. Disorders of thrombocyte function as a cause of postoperative hemorrhage after tonsillectomy. HNO. 1995;43:177-181.
  • Marshall JS, Weisberger AS, Levy RP. Coexistent idiopathic thrombocytopenic purpura and hyperthyroidism. Ann Intern Med. 1967;67:411–414.
  • Myrup B, Bregengard C, Faber J. Primary haemostasis in thyroid disease. J Intern Med. 1995;238:59–63.
  • Palareti G, Biagi G, Legnani C. Association of reduced factor VIII with impaired platelet reactivity to adrenalin and collagen after total thyroidectomy. Thromb Haemost. 1989;62:1053– 1056.
  • Feng S, Kroll MH, Nick AM, Anil K, Sood AK, Kharghan VA. Platelets are not hyperreactive in patients with ovarian cancer. Platelets. 2016;27:716–718.
  • Demirbaş MY, Gülsever M, Bozkurt AK. Buerger hastalığında ADP ve kollajen ile tetiklenmiş trombosit agregasyonu yanıtlarının sağlıklı kişilerle karşılaştırılması. Turkish J Thorac Cardiovasc Surg. 2009;17:106-109.
  • Jilma B. Platelet function analyzer (PFA-100): a tool to quantify congenital or acquired platelet dysfunction. J Lab Clin Med. 2001;138:152-163.
  • Favaloro EJ. Clinical utility of the PFA-100. Semin Thromb Hemost. 2008;34:709-733.

İdiyopatik Subjektif Tinnituslu Hastaların Trombosit Fonksiyonlarının Değerlendirilmesi

Yıl 2022, Cilt: 17 Sayı: 2, 155 - 159, 15.07.2022
https://doi.org/10.17517/ksutfd.1050504

Öz

Amaç: Bu çalışmada, idiyopatik subjektif tinnituslu hastalarda, trombosit fonksiyonları değerlendirildi. Bu amaçla trombositlerin agonistlere cevap olarak yaptıkları agregasyon eğrisini inceleyen bir test olarak kullanılan adenozin difosfat (ADP) ve kollajen ile tetiklenen trombosit agregasyon düzeyleri araştırıldı.
Gereç ve Yöntemler: Çalışmaya, kliniğe en az 1 yıldır devam eden idiyopatik subjektif tinnitus şikâyeti olan hastalar alındı. İdioyopatik subjektif tinnitusu olan otuz üç hasta ve tinnitus şikayeti olmayan 33 kontrol grubu olmak üzere toplamda 66 kişi dâhil edildi. Tinnitus Handikap İndeksi (THI), tinnitus şiddetini
ölçmek için tüm hastalar tarafından dolduruldu. Hastalardan alınan kanda, trombosit sayısı, protrombin zamanı (PT), parsiyel tromboplastin zamanı (aPTT), çalışıldı. Kanda adenozin difosfat kollajenaz (ADP) ve epinefrin kollajenaz ölçüldü. ADP ve kollajen, bir Chrono-log trombosit agregometre cihazında bir
Chrono-log kiti kullanılarak ölçüldü.
Bulgular: THI’ya göre evre 1’de 4 hasta (%12.1), evre 2’de 8 hasta (%24.2), evre 3’de 10 hasta (%30.3), evre 4’de 7 hasta (%21.2), ve evre 5’de 4 hasta (%12.1) mevcuttu. Tinnituslu hastalarda ADP ile tetiklenen agregasyonda ortalama değer 83.85±16.80 (%), kontrol grubunda ise 91.88±20.67 (%) bulundu
ve istatistiksel olarak anlamlı bir fark saptanmadı (p>0.05). Kollajen ile tetiklenen trombosit agregasyonunda tinnituslu hastalarda ortalama değer %119.24±24.76, kontrol grubunda %130.79±38.73 idi ve istatistiksel olarak anlamlı bir fark saptanmadı (p>0.05).
Sonuç: Sonuç olarak, trombosit fonksiyonları idiopatik subjektif tinnituslu hastalarda normal olarak değerlendirildi. Ancak, ölçülen değerlerin kontrol grubuna göre daha düşük olmasından dolayı trombosit agregasyonuna eğilimli olduğu tespit edildi.

Kaynakça

  • Nondahl DM, Cruickshanks KJ, Wiley TL, Klein R, Klein BE, Tweed TS. Prevalence and 5-year incidence of tinnitus among older adults: The epidemiology of hearing loss study. J Am Acad Audiol. 2002;13:323-331.
  • Jastreboff PJ, Gray WC, Mattox DE. Tinnitus and hyper acusis. In: Cummings CW, Fredrickson JM, Harker LA, Krause CJ, Richardson MA, Schuller DE, (eds). Otolaryngology Head and Neck Surgery. 3rd ed. Philadelphia: Mosby year Book; 1998.
  • Davis A, El Rafaie A. Epidemiology of tinnitus. In: Tyler RS, ed. Tinnitus handbook. San Diego, CA: Singular, Thomson Learning, 2000:1–23.
  • Baguley D, McFerran D, Hall D. Tinnitus. Lancet. 2013;382:1600–1607.
  • De Ridder D, Verstraeten E, Van der Kelen K, De Mulder G, Sunaert S, Verlooy J et al. Transcranial magnetic stimulation for tinnitus: influence of tinnitus duration on stimulation parameter choice and maximal tinnitus suppression. Otol Neurotol. 2005;26:616–619.
  • Norena A, Micheyl C, Chery-Croze S, Collet L. Psycho acoustic characterization of the tinnitus spectrum: implications for the underlying mechanisms of tinnitus. Audiol Neuro Otol. 2002;7:358–369.
  • Schecklmann M, Vielsmeier V, Steffens T, Landgrebe M, Langguth B, Kleinjung T. Relationship between audiometric slope and tinnitus pitch in tinnitus patients: insights into the mechanisms of tinnitus generation. PLoS One. 2012;7:e34878.
  • Schaette R, McAlpine D. Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model. J Neurosci. 2011;31:13452–13457.
  • Weisz N, Hartmann T, Dohrmann K, Schlee W, Norena A. High- frequency tinnitus without hearing loss does not mean absence of deafferentation. Hear Res. 2006;222:108–114.
  • McKenna L, Hallam RS, Hinchcliffe R. The prevalence of psychological disturbance in neuro-otology outpatients. Clin Otolaryngol Allied Sci. 1991;16:452–456.
  • Saldanha AD, Hilgenberg PB, Pinto LM, Conti PC. Are temporomandibular disorders and tinnitus associated? Cranio. 2012;30:166–171.
  • Born GV. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature. 1962;194:927–929.
  • O’Brien JR. The adhesiveness of native platelets and its prevention. J Clin Pathol. 1961;14:140–149.
  • Favaloro EJ. Clinical application of the PFA-100. Curr Opin Hematol. 2002; 9:407-415.
  • Franchini M. The platelet function analyzer (PFA-100): an update on its clinical use. Clin Lab. 2005;51:367-372.
  • Dikmen ZG, Akbıyık F. Trombosit fonksiyon testleri. Turk J Biochem. 2014;39:549–553.
  • Eggermont J, Roberts L. The neuroscience of tinnitus. Trends Neurosci. 2004;27:676–682.
  • Noreña AJ. An integrative model of tinnitus based on a central gain controlling neura lsensitivity. Neurosci Biobehav Rev. 2011;35:1089–1109.
  • Nondahl DM, Cruickshanks KJ, Huang GH, Klein BE, Klein R, Nieto FJ et al. Tinnitus and its risk factors in the Beaver Dam off spring study. Int J Audiol. 2011;50:313–320.
  • Daemen MA, van’tVeer C, Denecker G, Heemskerk VH, Wolfs TG, Clauss M et al. Inhibition of apoptosis induced by ischemia- reperfusion prevents inflammation. J Clin Invest. 1999;104:541–549.
  • Ozbay I, Kahraman C, Balikci HH, Kucur C, Kahraman NK, Ozkaya DP et al. Neutrophil-to-lymphocyte ratio in patients with severe tinnitus: prospective, controlled clinical study. J Laryngol Otol. 2015;129:544–547.
  • Kemal O, Muderris T, Basar F, Kutlar G, Gul F. Prognostic value of mean platelet volume on tinnitus. J Laryngol Otol. 2015;14:1–4.
  • Del Vecchio A, Motta M, Romagnoli C. Neonatal platelet function. Clin Perinatol. 2015;42:625–638.
  • Cattaneo M, Gachet C. ADP receptors and clinical bleeding disorders. Arterioscler Thromb Vasc Biol. 1999;19:2281-2285.
  • Rao AK. Congenital disorders of platelet function. In: Colman RW, Rao AK, (eds). Platelets in Health and Disease: Hematol/ OncolClin North Am. 1990.
  • Cattaneo M. Hereditary defect of theplatelet ADP receptor(s). Platelets. 1998;8:161–164.
  • Israels SJ, Cheang T, McMillan-Ward EM, Cheang M. Evaluation of primary hemostasis in neonates with a new in vitro platelet function analyzer. J Pediatr. 2001;138:116–119.
  • Eistert B, Kirchmaier C, Risse M, Glanz H. Disorders of thrombocyte function as a cause of postoperative hemorrhage after tonsillectomy. HNO. 1995;43:177-181.
  • Marshall JS, Weisberger AS, Levy RP. Coexistent idiopathic thrombocytopenic purpura and hyperthyroidism. Ann Intern Med. 1967;67:411–414.
  • Myrup B, Bregengard C, Faber J. Primary haemostasis in thyroid disease. J Intern Med. 1995;238:59–63.
  • Palareti G, Biagi G, Legnani C. Association of reduced factor VIII with impaired platelet reactivity to adrenalin and collagen after total thyroidectomy. Thromb Haemost. 1989;62:1053– 1056.
  • Feng S, Kroll MH, Nick AM, Anil K, Sood AK, Kharghan VA. Platelets are not hyperreactive in patients with ovarian cancer. Platelets. 2016;27:716–718.
  • Demirbaş MY, Gülsever M, Bozkurt AK. Buerger hastalığında ADP ve kollajen ile tetiklenmiş trombosit agregasyonu yanıtlarının sağlıklı kişilerle karşılaştırılması. Turkish J Thorac Cardiovasc Surg. 2009;17:106-109.
  • Jilma B. Platelet function analyzer (PFA-100): a tool to quantify congenital or acquired platelet dysfunction. J Lab Clin Med. 2001;138:152-163.
  • Favaloro EJ. Clinical utility of the PFA-100. Semin Thromb Hemost. 2008;34:709-733.
Toplam 35 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Araştırma Makaleleri
Yazarlar

Saime Sağıroğlu 0000-0003-2608-7274

Metin Kılınç 0000-0002-1623-0201

Muhammed Gazi Yıldız 0000-0002-1880-0685

İrfan Kara 0000-0002-5033-7424

Nagihan Bilal 0000-0002-2850-3481

İsrafil Orhan 0000-0002-9557-7050

Erken Görünüm Tarihi 11 Temmuz 2022
Yayımlanma Tarihi 15 Temmuz 2022
Gönderilme Tarihi 29 Aralık 2021
Kabul Tarihi 7 Mart 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 17 Sayı: 2

Kaynak Göster

AMA Sağıroğlu S, Kılınç M, Yıldız MG, Kara İ, Bilal N, Orhan İ. An Evaluation of Thrombocyte Functions in Patients with Idiopathic Subjective Tinnitus. KSÜ Tıp Fak Der. Temmuz 2022;17(2):155-159. doi:10.17517/ksutfd.1050504