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Ani İşitme Kaybında C-Reaktif Protein Albümin Oranı ve Hematolojik Parametrelerin Prognostik Değeri

Yıl 2023, Cilt: 5 Sayı: 3, 158 - 163, 01.11.2023

Muhammed Gazi Yıldız İsrafil Orhan Adem Doğaner

https://doi.org/10.38175/phnx.1239411

Öz

Amaç: Çalışmanın amacı Ani İşitme Kaybının(AİK) prognozunda C reaktif protein / albümin oranı(CAO) ve hemoglobin, nötrofil, lenfosit, trombosit, ortalama trombosit hacmi(MPV), Nötrofil/Lenfosit oranı(NLO), Trombosit / Lenfosit oranı(TLO) ve Sistemik İmmun İnflamasyon İndeksi(Sİİ) gibi hematolojik parametrelerin etkisini araştırmaktır.
Gereç ve Yöntemler: Çalışma 66 AİK tanısı olan hasta grubu ve 66 sağlıklı kontrol grubu olacak şekilde planlandı. Hastaların tedavi öncesi hemogram parametreleri ve işitme testleri incelendi. Ani işitme kaybı olan hastalar tedavi sonrası iyileşenler ve iyileşmeyenler olarak sınıflandırıldı. Gruplar arası CAO ve hematolojik parametreler karşılaştırıldı.
Bulgular: Hasta grupta CRP hariç diğer parametreler istatistiksel olarak anlamlı saptandı. Recevier Operator Curve(ROC) analizinde hasta grupta NLO, TLO, Sİİ, MPV ve CAO değerlerinin AİK grubunda ayrım gücü istatistiksel olarak anlamlı idi. Ayrıca AİK grubunda iyileşmeyenlerde ise nötrofil dışındaki diğer parametreler istatistiksel olarak anlamlı idi. ROC analizinde ise NLO, TLO, Sİİ, MPV ve CAO değerleri istatistiksel anlamlı yüksek saptandı.
Sonuç: Ani işitme kaybı olan hastalarda maliyeti düşük, kolay elde edilen CAO, NLO, TLO,MPV ve Sİİ prognozun belirlenmesinde prediktif gösterge olarak kullanılabilir.

Anahtar Kelimeler

Ani işitme kaybı C Reaktif Protein Albümin Oranı Hematolojik parametreler Sudden Hearing Loss C Reactive Protein Albumin Ratio Hematological Parameters

Kaynakça

  • Chandrasekhar SS, Tsai Do BS, Schwartz SR, Bontempo LJ, Faucett EA, Finestone SA, et al. Clinical Practice Guideline: Sudden Hearing Loss (Update). Otolaryngol Head Neck Surg. 2019;161(1_suppl):S1-S45. doi: 10.1177/0194599819859885.
  • Stachler RJ, Chandrasekhar SS, Archer SM, Rosenfeld RM, Schwartz SR, Barrs DM, et al. American Academy of Otolaryngology-Head and Neck Surgery. Clinical practice guideline: sudden hearing loss. Otolaryngol Head Neck Surg. 2012;146(3 Suppl):S1-35. doi: 10.1177/0194599812436449.
  • Matthew R, O’Malley, MD, David S. Sudden Hearing Loss. Otolaryngol Clin N Am 2008;633-49.
  • Coelho DH, Thacker LR, Hsu DW. Variability in the management of idiopathic sudden sensorineural hearing loss. Otolaryngol Head Neck Surg. 2011;145(5):813-817.
  • Masuda M, Kanzaki S, Minami S, Kikuchi J, Kanzaki J, Sato H, Ogawa K. Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol. 2012;33(7):1142-50. doi: 10.1097/MAO.0b013e3182635417.
  • Póvoa P, Coelho L, Almeida E, Fernandes A, Mealha R, Moreira P, Sabino H. Pilot study evaluating C-reactive protein levels in the assessment of response to treatment of severe bloodstream infection. Clin Infect Dis. 2005;40(12):1855-7. doi: 10.1086/430382.
  • Don BR, Kaysen G. Serum albumin: relationship to inflammation and nutrition. Semin Dial 2004; 17: 432-427.
  • Iskandar HN, Ciorba MA. Biomarkers in inflammatory bowel disease: current practices and recent advances. Transl Res 2012; 159: 313-325.
  • Sinan M, Ertan, NZ , Yalçın, Ö, Mirasoğlu, B. Ani İşitme Kaybı (AİK) Hastalarının Hemoreolojik Parametrelerinin İncelenmesi . Tıp Fakültesi Klinikleri Dergisi. 2020;3(1):25-33.
  • Tan M , Cengiz DU , Karakaş O, Bayindir, T. Ani İşitme Kayıplı Hastalarda Rutin Hemogram İçindeki İnflamatuar Markırların Prognoza Etkisi. İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi. 2021;9(1):130-9.
  • Aydoğdu İ, Yıldırım G, Kumral TL, Saltürk Z, Aydoğdu Z, İnan M, Uyar Y. Ani işitme kaybı olan hastalarda yeni prognostik parametreler: Nötrofil/lenfosit oranı ve Platelet/lenfosit oranı. Ok meydanı Tıp Dergisi. 2017;33(1):1-5.
  • Siegel LG. The treatment of idiopathic sudden sensorineural hearing loss. Otolaryngologic Clinics of North America 1975;8:467-73.
  • Wang Y-T, Su H-H, Hou Y, Chu S-T, Lai P-H, Tseng H-H, et al. Diffuse large B-cell lymphoma of the cerebellopontine angle in a patient with sudden hearing loss and facial palsy. J Chin Med Assoc. 2007;70(7):294–297. doi: 10.1016/S1726-4901(07)70008-4.
  • Hiramatsu M, Teranishi M, Uchida Y, Nishio N, Suzuki H, Kato K, et al. Polymorphisms in genes involved in inflammatory pathways in patients with sudden sensorineural hearing loss. J Neurogenet. 2012;26(3-4):387-96. doi: 10.3109/01677063.2011.652266.
  • Ho KM, Lee KY, Dobb GJ, Webb SA. C-reactive protein concentration as a predictor of in-hospital mortality after ICU discharge: a prospective cohort study. Intensive Care Med. 2008;34(3):481-7. doi: 10.1007/s00134-007-0928-0.
  • Domínguez de Villota E, Mosquera JM, Rubio JJ, Galdos P, Díez Balda V, de la Serna JL, Tomás MI. Association of a low serum albumin with infection and increased mortality in critically ill patients. Intensive Care Med. 1980;7(1):19-22. doi: 10.1007/BF01692917.
  • Öçal R, Akın Öçal FC, Güllüev M, Alataş N. Is the C-reactive protein/albumin ratio a prognostic and predictive factor in sudden hearing loss? Braz J Otorhinolaryngol. 2020;86(2):180-184. doi: 10.1016/j.bjorl.2018.10.007.
  • Cayir S, Kayabasi S, Hizli O. Predictor parameters for poor prognosis in patients with sudden sensorineural hearing loss: fibrinogen to albumin ratio vs C-reactive protein to albumin ratio. Braz J Otorhinolaryngol. 2021;87(4):457-61.
  • Shah AR, Chaudhari SN, Shah MH. Role of platelet parameters in diagnosis various clinical conditions. National journal of medical research 2013; 3(2): 162–5.
  • Kum RO, Ozcan M, Baklaci D, Yurtsever Kum N, Yilmaz YF, Unal A, Avci Y. Investigation of neutrophil-to-lymphocyte ratio and mean platelet volume in sudden hearing loss. Braz J Otorhinolaryngol. 2015;81(6):636-41. doi: 10.1016/j.bjorl.2015.08.009.
  • Sagit M, Kavugudurmaz M, Guler S, Somdas MA. Impact of mean platelet volume on the occurrence and severity of sudden sensorineural hearing loss. J Laryngol Otol. 2013;127(10):972-6. doi: 10.1017/S002221511300193X.
  • Kuhn M, Heman-Ackah SE, Shaikh JA, Roehm PC. Sudden sensorineural hearing loss: a review of diagnosis, treatment, and prognosis. Trends Amplif. 2011;15(3):91-105. doi: 10.1177/1084713811408349.
  • Seo YJ, Jeong JH, Choi JY, Moon IS. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss. Dis Markers. 2014;2014:702807. doi: 10.1155/2014/702807. .
  • Mirvakili A, Dadgarnia MH, Baradaranfar MH, Atighechi S, Zand V, Ansari A. Role of Platelet Parameters on Sudden Sensorineural Hearing Loss: A Case-Control Study in Iran. PLoS One. 2016;11(2):e0148149. doi: 10.1371/journal.pone.0148149. Erratum in: PLoS One. 2016;11(7):e0159695.
  • Sancaktar ME, Ağrı İ, Çeçen AB, Akgül G, Çelebi M. The Prognostic Value of Circulating Inflammatory Cell Counts in Sudden Sensorineural Hearing Loss and the Effect of Cardiovascular Risk Factors. Ear Nose Throat J. 2020;99(7):464-469. doi: 10.1177/0145561320920968.
  • Durmuş K, Terzi H, Karataş TD, Doğan M, Uysal IÖ, Şencan M, Altuntaş EE. Assessment of Hematological Factors Involved in Development and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss. J Craniofac Surg. 2016;27(1):e85-91. doi: 10.1097/SCS.0000000000002241.
  • Cao Z, Li Z, Xiang H, Huang S, Gao J, Zhan X, et al. Prognostic role of haematological indices in sudden sensorineural hearing loss: Review and meta-analysis. Clin Chim Acta. 2018;483:104-111. doi: 10.1016/j.cca.2018.04.025.

The Prognostic Importance of C-Reactive Poretin Albumin Ratio and Hematological Parameters in Sudden Hearing Loss

Yıl 2023, Cilt: 5 Sayı: 3, 158 - 163, 01.11.2023

Muhammed Gazi Yıldız İsrafil Orhan Adem Doğaner

https://doi.org/10.38175/phnx.1239411

Öz

Objective: The aim of the study was to investigate the effect of hemoglobin, neutrophil, lymphocyte, platelet, mean platelet volume (MPV), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), C reactive protein to albumin ratio (CAR), systemic immun inflamation index(SII) on the prognosis of sudden hearing loss.
Material and Methods: This study was planned as 66 patient group with AIC and 66 healthy control group.Routine hemogram parameters and hearing tests of the patients before treatment and control group were examined. patients with sudden hearing loss were classified as those who recovered after treatment and those who did not. CAR and hematological parameters were compared between groups.
Results: Except for CRP, other parameters were statistically significant in the patient group. In the Recevier Operator Curve (ROC) analysis, the discrimination power of NLR, TLR, SII, MPV and CAO values in the patient group was statistically significant. In addition, other parameters other than neutrophils were statistically significant in those who did not improve in the AIK group. NLR, TLR, SII, MPV and CAR values were found to be statistically significantly higher in the ROC analysis.
Conclusion: Cost-effective and easily obtained CAR, NLR, TLR, MPV and SII can be used as predictive markers in determining the prognosis in patients with sudden hearing loss.

Anahtar Kelimeler

Sudden Hearing Loss C Reactive Protein Albumin Ratio Hematological Parameters

Kaynakça

  • Chandrasekhar SS, Tsai Do BS, Schwartz SR, Bontempo LJ, Faucett EA, Finestone SA, et al. Clinical Practice Guideline: Sudden Hearing Loss (Update). Otolaryngol Head Neck Surg. 2019;161(1_suppl):S1-S45. doi: 10.1177/0194599819859885.
  • Stachler RJ, Chandrasekhar SS, Archer SM, Rosenfeld RM, Schwartz SR, Barrs DM, et al. American Academy of Otolaryngology-Head and Neck Surgery. Clinical practice guideline: sudden hearing loss. Otolaryngol Head Neck Surg. 2012;146(3 Suppl):S1-35. doi: 10.1177/0194599812436449.
  • Matthew R, O’Malley, MD, David S. Sudden Hearing Loss. Otolaryngol Clin N Am 2008;633-49.
  • Coelho DH, Thacker LR, Hsu DW. Variability in the management of idiopathic sudden sensorineural hearing loss. Otolaryngol Head Neck Surg. 2011;145(5):813-817.
  • Masuda M, Kanzaki S, Minami S, Kikuchi J, Kanzaki J, Sato H, Ogawa K. Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol. 2012;33(7):1142-50. doi: 10.1097/MAO.0b013e3182635417.
  • Póvoa P, Coelho L, Almeida E, Fernandes A, Mealha R, Moreira P, Sabino H. Pilot study evaluating C-reactive protein levels in the assessment of response to treatment of severe bloodstream infection. Clin Infect Dis. 2005;40(12):1855-7. doi: 10.1086/430382.
  • Don BR, Kaysen G. Serum albumin: relationship to inflammation and nutrition. Semin Dial 2004; 17: 432-427.
  • Iskandar HN, Ciorba MA. Biomarkers in inflammatory bowel disease: current practices and recent advances. Transl Res 2012; 159: 313-325.
  • Sinan M, Ertan, NZ , Yalçın, Ö, Mirasoğlu, B. Ani İşitme Kaybı (AİK) Hastalarının Hemoreolojik Parametrelerinin İncelenmesi . Tıp Fakültesi Klinikleri Dergisi. 2020;3(1):25-33.
  • Tan M , Cengiz DU , Karakaş O, Bayindir, T. Ani İşitme Kayıplı Hastalarda Rutin Hemogram İçindeki İnflamatuar Markırların Prognoza Etkisi. İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi. 2021;9(1):130-9.
  • Aydoğdu İ, Yıldırım G, Kumral TL, Saltürk Z, Aydoğdu Z, İnan M, Uyar Y. Ani işitme kaybı olan hastalarda yeni prognostik parametreler: Nötrofil/lenfosit oranı ve Platelet/lenfosit oranı. Ok meydanı Tıp Dergisi. 2017;33(1):1-5.
  • Siegel LG. The treatment of idiopathic sudden sensorineural hearing loss. Otolaryngologic Clinics of North America 1975;8:467-73.
  • Wang Y-T, Su H-H, Hou Y, Chu S-T, Lai P-H, Tseng H-H, et al. Diffuse large B-cell lymphoma of the cerebellopontine angle in a patient with sudden hearing loss and facial palsy. J Chin Med Assoc. 2007;70(7):294–297. doi: 10.1016/S1726-4901(07)70008-4.
  • Hiramatsu M, Teranishi M, Uchida Y, Nishio N, Suzuki H, Kato K, et al. Polymorphisms in genes involved in inflammatory pathways in patients with sudden sensorineural hearing loss. J Neurogenet. 2012;26(3-4):387-96. doi: 10.3109/01677063.2011.652266.
  • Ho KM, Lee KY, Dobb GJ, Webb SA. C-reactive protein concentration as a predictor of in-hospital mortality after ICU discharge: a prospective cohort study. Intensive Care Med. 2008;34(3):481-7. doi: 10.1007/s00134-007-0928-0.
  • Domínguez de Villota E, Mosquera JM, Rubio JJ, Galdos P, Díez Balda V, de la Serna JL, Tomás MI. Association of a low serum albumin with infection and increased mortality in critically ill patients. Intensive Care Med. 1980;7(1):19-22. doi: 10.1007/BF01692917.
  • Öçal R, Akın Öçal FC, Güllüev M, Alataş N. Is the C-reactive protein/albumin ratio a prognostic and predictive factor in sudden hearing loss? Braz J Otorhinolaryngol. 2020;86(2):180-184. doi: 10.1016/j.bjorl.2018.10.007.
  • Cayir S, Kayabasi S, Hizli O. Predictor parameters for poor prognosis in patients with sudden sensorineural hearing loss: fibrinogen to albumin ratio vs C-reactive protein to albumin ratio. Braz J Otorhinolaryngol. 2021;87(4):457-61.
  • Shah AR, Chaudhari SN, Shah MH. Role of platelet parameters in diagnosis various clinical conditions. National journal of medical research 2013; 3(2): 162–5.
  • Kum RO, Ozcan M, Baklaci D, Yurtsever Kum N, Yilmaz YF, Unal A, Avci Y. Investigation of neutrophil-to-lymphocyte ratio and mean platelet volume in sudden hearing loss. Braz J Otorhinolaryngol. 2015;81(6):636-41. doi: 10.1016/j.bjorl.2015.08.009.
  • Sagit M, Kavugudurmaz M, Guler S, Somdas MA. Impact of mean platelet volume on the occurrence and severity of sudden sensorineural hearing loss. J Laryngol Otol. 2013;127(10):972-6. doi: 10.1017/S002221511300193X.
  • Kuhn M, Heman-Ackah SE, Shaikh JA, Roehm PC. Sudden sensorineural hearing loss: a review of diagnosis, treatment, and prognosis. Trends Amplif. 2011;15(3):91-105. doi: 10.1177/1084713811408349.
  • Seo YJ, Jeong JH, Choi JY, Moon IS. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss. Dis Markers. 2014;2014:702807. doi: 10.1155/2014/702807. .
  • Mirvakili A, Dadgarnia MH, Baradaranfar MH, Atighechi S, Zand V, Ansari A. Role of Platelet Parameters on Sudden Sensorineural Hearing Loss: A Case-Control Study in Iran. PLoS One. 2016;11(2):e0148149. doi: 10.1371/journal.pone.0148149. Erratum in: PLoS One. 2016;11(7):e0159695.
  • Sancaktar ME, Ağrı İ, Çeçen AB, Akgül G, Çelebi M. The Prognostic Value of Circulating Inflammatory Cell Counts in Sudden Sensorineural Hearing Loss and the Effect of Cardiovascular Risk Factors. Ear Nose Throat J. 2020;99(7):464-469. doi: 10.1177/0145561320920968.
  • Durmuş K, Terzi H, Karataş TD, Doğan M, Uysal IÖ, Şencan M, Altuntaş EE. Assessment of Hematological Factors Involved in Development and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss. J Craniofac Surg. 2016;27(1):e85-91. doi: 10.1097/SCS.0000000000002241.
  • Cao Z, Li Z, Xiang H, Huang S, Gao J, Zhan X, et al. Prognostic role of haematological indices in sudden sensorineural hearing loss: Review and meta-analysis. Clin Chim Acta. 2018;483:104-111. doi: 10.1016/j.cca.2018.04.025.
Toplam 27 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Kulak Burun Boğaz
Bölüm Araştırma Makaleleri
Yazarlar

Muhammed Gazi Yıldız 0000-0002-1880-0685

İsrafil Orhan 0000-0002-9557-7050

Adem Doğaner 0000-0002-0270-9350

Erken Görünüm Tarihi 24 Ekim 2023
Yayımlanma Tarihi 1 Kasım 2023
Gönderilme Tarihi 19 Ocak 2023
Kabul Tarihi 11 Temmuz 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 5 Sayı: 3

Kaynak Göster

Vancouver Yıldız MG, Orhan İ, Doğaner A. Ani İşitme Kaybında C-Reaktif Protein Albümin Oranı ve Hematolojik Parametrelerin Prognostik Değeri. Phnx Med J. 2023;5(3):158-63.
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