FABRICATION OF COPPER OXIDE NANOPARTICLES DOPED PCL/PVP NANOFIBROUS MATS BY ELECTROSPINNING AND EVALUATION OF THEIR ANTIBACTERIAL ACTIVITIES

Fatih Erci; Fatma Bayram Sarıipek

doi:10.17780/ksujes.1290143

EN TR

FABRICATION OF COPPER OXIDE NANOPARTICLES DOPED PCL/PVP NANOFIBROUS MATS BY ELECTROSPINNING AND EVALUATION OF THEIR ANTIBACTERIAL ACTIVITIES

Abstract

In this study, PCL/PVP/CuO nanofibrous mats for antibacterial applications were fabricated by electrospinning technique using PCL/PVP as a biopolymer matrix and copper oxide nanoparticles (CuONPs) as antimicrobial agents. PCL/PVP/CuO nanofibrous mats were successfully produced by doping different ratios of CuONPs (0.5%, 1%, and 2% wt) into the PCL/PVP solution. The chemical, morphological, and wetting properties of the prepared composite nanofibrous mats were evaluated by FT-IR, FE-SEM analysis, and water contact angle measurements. The morphological investigation indicated that the fiber diameters of the resulting nanofibers decreased as the CuONP content added to the PCL/PVP matrix increased, and the mean fiber diameter value measured for the PCL/PVP/2%CuONPs nanofibrous sample was 186.73. Moreover, wetting behavior of nanofiber surfaces displayed that the incorporation of PVP significantly enhanced the surface wettability of PCL with hydrophobic properties, but the addition of CuONPs to the obtained PCL/PVP matrix decreased it. An in vitro bactericidal assay was performed to investigate the efficacy of PCL/PVP/CuO nanofibrous samples against Staphylococcus aureus. The addition of CuONPs to the fibers led to antibacterial activity, which was found to increase with higher doping ratios. The results showed the potential of PCL/PVP/CuO nanofibrous mats to serve as an effective biomaterial for antibacterial applications.

Keywords

BAKIR OKSİT NANOPARTİKÜL KATKILI PCL/PVP NANOLİFLİ MATLARIN ELEKTROÇEKİM İLE ÜRETİMİ VE ANTİBAKTERİYEL AKTİVİTELERİNİN DEĞERLENDİRİLMESİ

Öz

Bu çalışmada, biyopolimer matris olarak PCL/PVP ve antimikrobiyal ajan olarak bakır oksit nanopartikülleri (CuONPs) kullanılarak elektroçekim tekniği ile antibakteriyel uygulamalar için PCL/PVP/CuO nanolifli matlar üretildi. PCL/PVP/CuO nanolifli matlar, PCL/PVP çözeltisine farklı oranlarda CuONPs’in (ağırlıkça %0,5, %1 ve %2) katkılanmasıyla başarılı bir şekilde üretildi. Hazırlanan kompozit nanolifli matların kimyasal, morfolojik ve ıslanma özellikleri FT-IR, FE-SEM analizleri ve temas açısı ölçümü ile değerlendirildi. Morfolojik inceleme, PCL/PVP matrisine eklenen CuONPs içeriği arttıkça sonuçlanan nanoliflerin lif çaplarının azaldığını ve PCL/PVP/2%CuONPs nanolifli örneği için ölçülen ortalama lif çapı değerinin 186.73o olduğunu gösterdi. Dahası, nanolif yüzeylerinin ıslanma davranışı, PVP'nin dahil edilmesinin, hidrofobik özelliklere sahip PCL'ın yüzey ıslanabilirliğini önemli ölçüde arttırırken ancak elde edilen PCL/PVP matrise CuONPs ilavesinin ise azalttığını gösterdi. PCL/PVP/CuO nanoliflli örneklerinin Staphylococcus aureus'a karşı etkinliğini araştırmak için bir in vitro antibakteriyel aktivite testi gerçekleştirildi. CuONPs’ın liflere eklenmesi antibakteriyel aktiviteye yol açtı ve bu aktivitenin daha yüksek nanopartikül katkılanma oranlarıyla arttığı bulundu. Sonuçlar, PCL/PVP/CuO nanolifli matların antibakteriyel uygulamalar için etkili bir biyomalzeme olarak işlev görebilme potansiyelini gösterdi.

Anahtar Kelimeler

Thanks

In this study, the infrastructure of Necmettin Erbakan University Science and Technology Research and Application Center (BITAM) was used.

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Details

Primary Language

English

Subjects

Engineering

Journal Section

Research Article

Authors

Fatih Erci
0000-0002-3044-7343
Türkiye

Fatma Bayram Sarıipek ^*
0000-0001-8168-3517
Türkiye

Publication Date

December 3, 2023

Submission Date

April 30, 2023

Acceptance Date

June 19, 2023

Published in Issue

Year 2023 Volume: 26 Number: 4

DOI

https://doi.org/10.17780/ksujes.1290143

IZ

https://izlik.org/JA87YC76RL

Cite

RIS / Bibtex

APA

Erci, F., & Bayram Sarıipek, F. (2023). FABRICATION OF COPPER OXIDE NANOPARTICLES DOPED PCL/PVP NANOFIBROUS MATS BY ELECTROSPINNING AND EVALUATION OF THEIR ANTIBACTERIAL ACTIVITIES. Kahramanmaraş Sütçü İmam Üniversitesi Mühendislik Bilimleri Dergisi, 26(4), 823-833. https://doi.org/10.17780/ksujes.1290143

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